Astroprotein (an astrocyte-specific cerebroprotein) levels in cerebrospinal fluid (CSF) were determined by radioimmunoassay in 47 stroke patients. (Astroprotein is immunologically identical to glial fibrillary acidic protein.) Astroprotein levels in CSF increased markedly in acute cases of intracerebral hemorrhage and slightly to moderately in some acute cases of subarachnoid hemorrhage and cer...

• Improve the recognition, differential diagnosis, and management of seizures occurring in critically ill patients • Understand the pharmacology and application of newer anticonvulsant drugs in the ICU • Recognize and manage status epilepticus • Understand the special diagnostic and management issues of refractory status epilepticus • Improve recognition of patients with acute subarachnoid hemo...

CLINICAL QUESTION How many patients who had a negative computed tomography and lumbar puncture result on initial evaluation were diagnosed with subarachnoid hemorrhage in the subsequent 6 months to 3 years? ARTICLE CHOSEN Perry J, Spacek A, Forbes M, et al. Is the combination of negative computed tomography result and negative lumbar puncture result sufficient to rule out subarachnoid hemorrh...

Spinal hematoma is a rare and usually severe neurological disorder that, without adequate treatment, often leads to death or permanent neurological deficit. Epidural as well as subdural and subarachnoid hematomas have been investigated in some studies. A 66-year-old man referred to our hospital because of acute onset paraplegia and incontinency started 3 h before admission. With impression of s...

CLINICAL QUESTION Is lumbar puncture still needed in suspected subarachnoid hemorrhage with a negative head computed tomographic scan performed within 6 hours of headache onset? ARTICLE CHOSEN Perry JJ, Stiell IG, Sivilotti ML, et al. Sensitivity of computed tomography performed within six hours of onset of headache for diagnosis of subarachnoid haemorrhage: prospective cohort study. BMJ 2011...

BACKGROUND AND PURPOSE Although genetic epidemiologic studies have implicated several genetic variants as risk factors for ischemic or hemorrhagic stroke, the genetic determinants of these conditions remain largely unknown. We performed an association study to identify gene polymorphisms that confer susceptibility to atherothrombotic cerebral infarction, intracerebral hemorrhage, or subarachnoi...

A 62-year-old man was admitted with a hypertensive emergency, anisocoria and decreased level of consciousness. The CT scan showed a hemorrhage in the brainstem and an intraocular hemorrhage (Figure), consistent with Terson’s syndrome, a condition that is classically characterized as a vitreous hemorrhage secondary to a subarachnoid hemorrhage. However, it can also be considered as a traumatic h...

o bjectives: to determine the diagnostic accuracy of magnetic resonance angiography (mra) compared to intra-arterial digital subtraction angiography (dsa) in detection of intracranial aneurysms in those suffering from acute subarachnoid hemorrhage (sah). m e thods: this observational diagnostic study was performed at a tertiary teaching hospital and reference center in shiraz, iran. we included...

Background and Purpose: Aneurysmal subarachnoid hemorrhage is a serious disease despite recent improvements in medical and surgical treatment. Hence, identification of modifiable risk factors for subarachnoid hemorrhage is important. Methods: We compared the smoking and drinking habits of 278 consecutive patients with aneurysmal subarachnoid hemorrhage, aged 15-60 years (145 men and 133 women) ...

OBJECTIVE Preoperative selective particulate embolization of arteriovenous malformations can make subsequent surgical resection of such lesions safer for the patient and easier for the surgeon. Nevertheless, embolization carries intrinsic risks, which include subarachnoid hemorrhage. We report two cases of subarachnoid hemorrhage during particulate embolization that we think was attributable to...