The oxysterol-activated nuclear receptor liver X receptor alpha (LXRalpha) has been implicated in the control of both cholesterol and fatty acid metabolism. In this study, we have evaluated the effects of excess dietary cholesterol on hepatic cholesterol metabolism, lipogenesis, and VLDL production in homozygous (Lxralpha(-/-)), heterozygous (Lxralpha(+/-)), and wild-type mice. Mice were fed ei...

The present paper describes a marked induction of liver microsomal cytochrome P-450 and cytosolic DT-diaphorase to cause possible disorder of steroid homeostasis and promotion of carcinogenicity of 4-nitroquinoline N-oxide (4-NQO) in rats by pretreatment with 3,4,5,3',4'-pentachlorobiphenyl (PenCB) or 2,3,4,7,8-pentachlorodibenzofuran (PenCDF). The animals were sacrificed 5 days after the pretr...

Greater offspring predation favors evolution of faster development among species. We hypothesized that greater offspring predation exerts selection on mothers to increase levels of anabolic androgens in egg yolks to achieve faster development. Here, we tested whether (1) concentrations of yolk androgens in passerine species were associated with offspring predation and (2) embryo and nestling de...

In argumentation theory, Dung’s abstract framework provides a unifying view of several alternative semantics based on the notion of extension. Recently, a new semantics has been introduced to solve the problems related to counterintuitive results produced by literature proposals. In this semantics, extensions can be decomposed and constructed along the strongly connected components of the defea...

We construct twelve infinite families of pseudocyclic and non-amorphic association schemes, in which each nontrivial relation is a strongly regular graph. Three of the twelve families generalize the counterexamples to A. V. Ivanov’s conjecture by Ikuta and Munemasa [13].