Objective(s): The present paper aims to review the studies describing the interactions between HopQ and CEACAMs along with possible mechanisms responsible for pathogenicity of Helicobacter pylori.Materials and Methods: The literature was searched on “PubMed” using different key words including Helicobacter pylori, CEACAM and gastric.<br ...

The generalization capability of machine learning models, which refers to generalizing the knowledge for an “unseen” domain via from one or multiple seen domain(s), is great importance develop and deploy applications in real-world conditions. Domain Generalization (DG) techniques aim enhance such where learnt feature representation classifier are two crucial factors improve make decisions. In t...

cognitive science has found out that languages typically make use of conceptual metaphors to concretize abstract meanings. conceptual metaphor explains a target domain which is abstract via a source domain which is concrete. in other words, conceptual metaphor compares an abstract domain with a concrete one and thus makes it understandable for listeners/readers. this article studies the concept...

Interferon regulatory factors ( IRF s) are a family of transcription that control many facets during innate and adaptive immune responses. Vertebrate s play important roles in regulating the expression interferons (IFNs) IFN-stimulated genes, while only limited studies were conducted on invertebrate s. In present study, four genes CfIRF1, CfIRF1-like, CfIRF2 , CfIRF8 ) identified from Zhikong s...

Uch37 is a de-ubiquitylating enzyme that is functionally linked with the 26S proteasome via Rpn13, and is essential for metazoan development. Here, we report the X-ray crystal structure of full-length human Uch37 at 2.95 Å resolution. Uch37's catalytic domain is similar to those of all UCH enzymes characterized to date. The C-terminal extension is elongated, predominantly helical and contains c...

EVOLUTIONARY PSYCHOLOGY OFTEN does not sufficiently document the innate constraint and domain specificity required for strong adaptationist argument. We develop these criteria within the domain of music. First, we advocate combining computational, developmental, cross-cultural, and neuroscience research to address the ways in which a domain is innately constrained. Candidate constraints in musi...

SYD-2/liprin-α is a multi-domain protein that associates with and recruits multiple active zone molecules to form presynaptic specializations. Given SYD-2's critical role in synapse formation, its synaptogenic ability is likely tightly regulated. However, mechanisms that regulate SYD-2 function are poorly understood. In this study, we provide evidence that SYD-2's function may be regulated by i...

The first imported case of Middle East respiratory syndrome (MERS) in China recently occurred, allowing for the characterization of antibody titers in a series of the patient's sera using the following methods based on recombinant viral structural antigens: inactivated MERS coronavirus (MERS-CoV) enzyme-linked immunosorbent assay (ELISA), recombinant MERS-CoV spike (S, or fragments of S) ELISA,...