نتایج جستجو برای: stripped myometrium

تعداد نتایج: 5026  

2013
Bartosz WOJCIECHOWICZ Genowefa KOTWICA Justyna KOLAKOWSKA Anita FRANCZAK

Steroid hormones are produced by the porcine uterus. We hypothesized that the uterus in pigs possesses active 3β-hydroxysteroid dehydrogenase/Δ(5)-Δ(4) isomerase (3β-HSD) responsible for progesterone and androstenedione production, that uterine steroids may supplement the amount of steroid hormones produced by embryos and corpus luteum and that these steroids are necessary for maintenance of pr...

2013
Peter Turton Sarah Arrowsmith Jonathan Prescott Celia Ballard Leanne Bricker James Neilson Susan Wray

OBJECTIVE Over half of twin pregnancies in US and UK deliver prematurely but the reasons for this are unclear. The contractility of myometrium from twin pregnancies has not been directly investigated. The objective of this research was to determine if there are differences in the contractile activity and response to oxytocin, between myometrium from singleton and twin pregnancies, across a rang...

Journal: :Molecular human reproduction 2006
Xiaoping Luo Li Ding Nasser Chegini

Connective tissue growth factor (CTGF; CCN2) is considered to serve as downstream midiator of TGF-beta action in tissue fibrosis. We tested this hypothesis in paired leiomyoma and myometrium by evaluating the expression of TGF-beta1/TGF-beta3 and CCN2, the other members of the CCN family, CCN3 and CCN4, as well as fibulin-1C and S100A4, calcium-binding proteins that interact with CCNs. The regu...

2014
Carrington J. Morwood Martha Lappas Kang Sun

Spontaneous preterm birth is the leading cause of infant death and of neurological disabilities in survivors. A significant proportion of spontaneous preterm births are associated with infection. Infection activates inflammation which induces a cascade of events that leads to myometrial contractions and rupture of fetal membranes. In non-gestational tissues, the citrus flavone nobiletin has bee...

Journal: :Molecular human reproduction 2014
Juan M Gonzalez Silvia M A Pedroni Guillermina Girardi

Preterm birth (PTB) is a major public health problem, with a global prevalence of 9.6% and over a million annual neonatal deaths. In a mouse model of preterm labor (PTL) induced by intravaginal administration of a subclinical dose of lipopolysaccharide (LPS), we previously demonstrated that LPS ascends to the cervix, inducing complement activation, cervical remodeling and PTL. Here we show that...

Journal: :Journal of applied physiology 2005
Thérèse-Marie Mignot Brigitte Paris Bruno Carbonne Christian Vauge Françoise Ferré Daniel Vaiman

In this paper, we applied a new theoretical model of uterine contraction to a large panel of human pregnant and nonpregnant myometrial strips, treated or not by corticotrophin-releasing hormone (CRH). This model is based on a fine analysis of the contraction curves. This analysis yielded four mathematical parameters (beta, theta, tau 1, and tau 2) related to excitability, duration of plateau ph...

Journal: :Monthly Notices of the Royal Astronomical Society 2015

Journal: :Reproductive biology 2012
Anna Nitkiewicz Nina Smolinska Anna Maleszka Marta Kiezun Tadeusz Kaminski

The presence of orexins and their receptors in gonads indicate that these hormones participate in the control of reproductive functions. The aim of the study was to compare the expression of the prepro-orexin (PPO) gene in porcine endometrium and myometrium and the intensity of OXA- and OXB-immunoreactivity in the following uterine structures: endometrial glandular and luminal epithelium and st...

2014
Mette Rahbek Sasan Nazemi Lars Ødum Saurabh Gupta Steen Seier Poulsen Anders Hay-Schmidt Dan Arne Klaerke

Preterm births accounts for roughly 9% of all births worldwide and can have detrimental or even lethal consequences for the infant. However to develop new treatment that will lower the rate of preterm births, more knowledge is required on the factors contributing to the contraction and relaxation of the myometrium. The small conductance Ca²⁺-activated potassium channel subtype 3 (SK3) has been ...

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