objective(s): bidens species are used for their antidiabetic properties traditionally in many countries. aim of this study is to evaluate hypoglycaemic and antidiabetic activity of bidens tripartita extract and to identify its active compounds through bioactivity guided isolation technique. materials and methods: hypoglycaemic effects of b. tripartita extract and its sub-extracts were investiga...

The aim of the present study was to evaluate the effects of aqueous seed extract of Tephrosia purpurea (TpASet) on blood glucose and antioxidant status in streptozotocin induced diabetic rats. Hyperglycemia associated with an altered hexokinase and glucose-6-phosphatase activities, elevated lipid peroxidation, disturbed enzymatic [Superoxide dismutase (SOD), catalase (CAT) and glutathione perox...

Diabetic disease is known to suppress male reproductive activity in laboratory animals and humans. The present study was designed to evaluate whether streptozotocin-induced diabetes increases apoptotic cell death in rat testes through activation of the JNK and Bax pathway. Diabetes was induced by a single intravenous injection of streptozotocin (40 mg/kg) and testis samples were collected after...

The present study investigated the antilipoperoixdative and antioxidant effect of morin in normal and streptozotocin-induced diabetic Wistar rats. Diabetes as induced in rats by an intraperitoneal injection of streptozotocin. Morin was orally administered to normal and diabetic rats for a period of 45 days. In diabetic rats, thiobarbituric acid reactive substances and lipid hydroperoxides were ...

Amylin, a peptide copackaged with insulin in beta-cell granules, was measured in the effluent of the perfused rat pancreases by means of a newly developed specific radioimmunoassay. Its secretion parallels that of insulin in response to 20 mM glucose, 10 mM arginine, or the combination thereof. The relative molar amount of secreted amylin was estimated to be 25-37% that of insulin. Treatment wi...

Streptozotocin has been shown to induce the production of a variety of tumors in rats. The present report demonstrates that streptozotocin and 1-methyl-1-nitrosourea, a component of the streptozotocin molecule and a known carcinogen, stimulate the enzyme guanylate cyclase which catalyzes the production of guanosine 3',5'-monophosphate. At a maximal concentration of 3 mg/ml, these agents activat...

Introduction: Olibanum improves memory in different models of learning. However, the effect of olibanum on models of Alzheimer’s disease has been less studied. In the present study, the effect of olibanum on memory in normal rats and in a rat model of Alzheimer disease induced by intracerebroventricular injections of streptozotocin was evaluated. Methods: Rats received an aqueous extract of...

The petroleum ether extract of the root bark of S. oblonga Wall. (Celastraceae) (SOB) was studied in streptozotocin (STZ) diabetic rats and anti-lipid peroxidative activity of the same was studied in the cardiac tissue. SOB prevented significantly the streptozotocin-induced hyperglycaemia and hypoinsulinaemia. It also produced a significant decrease in peroxidation products viz. thiobarbituric ...

This study examines possible interactions between behavioral effects and influence of N-methyl-D-aspartate acid (NMDA) receptors in 4 and 12-week streptozotocin (STZ) induced diabetic rats. Effects of NMDA receptor agonist on spatial learning were tested in control groups of rats and in rats with 4 and 12 weeks diabetes mellitus (DM). Experimental diabetes was induced by a single intravenous in...

Green tea polyphenols have demonstrated significant antioxidant, anticarcinogenic, anti-mutagenic and antidiabetic in numerous human, animal and in vitro studies. Hence present study was design to evaluate the influence of green tea in streptozotocin induced oxidative stress in mice. Morris water maze, Elevated plus maze and passive avoidance apparatus was used for the evaluation of learning an...