In recent years the well known gruel test meal has given place to more precise tests of gastric secretion, measurements of the rate of emptying have been introduced into clinical practice and it has become possible to measure the stimulating hormone, gastrin. The whole subject has been admirably reviewed in a small paper-back by Professor Alastair Connell, now of Cincinnati, Ohio. In this book ...

This paper reports a follow-up of 91 healthy men who had a histamine gastric function test performed 28 years ago and relates the original gastric function test to the subsequent development of duodenal ulceration.

The work of Glass has suggested that glandular mucoprotein and mucoproteose can be isolated by a fractional precipitation method from gastric secretion. These studies have failed to confirm this hypothesis and point out a fallacy of the original technique used.

AIM To establish a modified B-ultrasound method of measuring the antral section only to assess gastric motility in healthy people, and evaluate its application in guiding enteral nutrition (EN) in critically ill patients. METHODS First, 30 healthy volunteers were selected. The modified B-ultrasound method and the traditional B-ultrasound method were applied to assess gastric function. The cor...

Cirrhotic ascites, in which secondary hyperaldosteronism is a notable feature, is associated with impaired gastric secretion (Baddeley, 1968). Obstruction to hepatic venous outflow, which also induces secondary hyperaldosteronism and ascites (Orloff, Ross, Baddeley, Nutting, Spitz, Sloop, Neesby, and Halasz, 1964), depresses acid secretion from Heidenhain pouches in dogs with cirrhotic and non-...

AIMS To study whether differences in eradication rates of antibiotics may be explained by differences in secretion of antibiotics in gastric juice. METHODS A single intravenous dose of either ampicillin 500 mg, erythromycin 500 mg, or metronidazole 500 mg was administered to four healthy Helicobacter pylori negative volunteers on different days. Antibiotic concentrations were measured in gast...

The pepsinogens of human gastric mucosa have been the subject of several studies using electrophoretic and chromatographic techniques (Uriel, 1960; Seijffers, Segal, and Miller, 1963; Tang and Tang, 1963; Kushner, Rapp, and Burtin, 1964; Rapp, Aronson, Burtin, and Grabar, 1964; Hanley, Boyer, and Naughton, 1966; Taylor, 1968; Samloff, 1969); it has been shown that gel electrophoresis is superio...

EDITORIAL SYNOPSIS The pattern of gastric secretion has been studied in a series of patients following the augmented histamine test and the insulin test. In the same patient, the amount of acid and pepsin secreted is remarkably similar following these two tests. In both, acid and pepsin secretion is inhibited to a similar degree by small doses of hexamethonium and atropine. It is concluded that...

The detection of immunological phenomena in pernicious anaemia (Schwartz, 1958; Taylor, 1959) introduced the concept of immunological assay of intrinsic factor. Several methods in which antibodies against intrinsic factor are used are now available (Jeffries and Sleisenger, 1965; Herbert, Gottlieb, Lau, and Wasserman, 1964; Abels, Bouma, Jansz, Woldring, Bakker, and Nieweg, 1963; Ardeman Chanar...

Human duodenal mucosal cells have been examined by mixed-cell agglutination for the presence of bloodgroup antigens. The secretor status of the patients has been determined, and in a proportion of cases gastric juice as well as saliva has been studied. Mixed-cell agglutination has also been performed on the buccal cells from a percentage of subjects as a control of technique. The results indica...