The effect of anticholinergic agents-atropine, propantheline, oxyphencyclimine, and propionyl atropine methyl nitrate-on silva flow and on hypoglycaemic stimulated gastric secretion has been studied. The acid secretion of the nervous phase of gastric secretion was inhibited by anticholinergic drugs. They influenced gastric secretion to a greater extent than saliva flow. Both propantheline and o...

BACKGROUND/AIMS Paraoxon, an organophosphate metabolite of the insecticide parathion inhibits the enzyme, acetylcholinesterase (Achase). Organophosphates affect the heart, visual system, nervous system and muscles. In this present study, we investigate the effects of the chronic consumption of paraoxon on gastric acid and pepsin secretion in N-mari rats. MATERIALS AND METHODS This study was p...

The present study was undertaken to investigate the possibility that central nervous system monoaminergic pathways may play a role in the control of gastric acid and gastrin secretion in man. Submaximal pentagastrin stimulated (0.25 micrograms/kg/h) gastric acid secretion, as well as basal gastrin concentrations were studied in two groups of subjects. The first group received oral administratio...

Gastric acid secretion is regulated by three primary components that activate the parietal cell: histamine, gastrin, and acetylcholine (ACh). Although much is known about these regulatory components individually, little is known on the interplay of these multiple activators and the degree of regulation they pose on the gastric acid secretion mechanism. We utilized a novel dual-sensing approach,...

Pituitary adenylate cyclase activating polypeptide (PACAP) is present in gastric nerves, and PACAP receptors (PAC1) are found on gastric enterochromaffin-like (ECL) cells. Expression of PAC1 splice variants in purified ECL cells was determined by RT-PCR. PACAP effects on ECL cells were analyzed by video imaging of [Ca(2+)](i) and histamine release; its effects on gastric glands were examined by...

BACKGROUND ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) is an inhibitor of both cyclooxygenase and 5-lipoxygenase in vitro, and shows promise as a novel non-steroidal anti-inflammatory drug (NSAID). Unlike conventional NSAIDs which are associated with gastric ulcerogenic effects, ML 3000 causes little or no damage to the gastric mucosa, even t...

Insulin-induced hypoglycaemia leads to vagally mediated stimulation of gastric secretion (Hollander, 1946). Insulin-induced hypoglycaemia also produces a stress response mediated by the sympathetic nervous system (Cannon, McIver, and Bliss, 1924; von Euler and Luft, 1952; Duner, 1954; Cantu, Wise, Goldfien, Gullixson, Fischer, and Ganong, 1963). Adrenaline and l-noradrenaline reduce basal and s...

Background—The cytokines interleukin 1â (IL-1â) and tumour necrosis factor á (TNF-á) are inhibitors of gastric acid secretion when administered systemically. Aims—To investigate the inhibitory eVect of IL-1â and TNF-á on cultured, acid secreting parietal cells in order to determine the mechanism of this inhibition. Methods—Rabbit parietal cells were prepared by collagenase-EDTA digestion and co...

It has been shown that those factors which affect gastric acid secretion through the ventromedial and lateral nuclei of hypothalamus, can significantly alter centrally-mediated secretion. There is much evidence that glucose is among these factors that through a central mechanism can decrease induced acid secretion. It appears that this effect is mediated through glucose-sensitive neurons within...

215 (4): 885-888. 1968.-The inhibitory effects of intravenous infusions of secretin and intraduodenal infusions of HCl on gastric secretion were compared in dogs having Heidenhain pouches, gastric and duodenal fistulas. With the gastric fistula open a constant level of secretion was established in the Heidenhain pouch with either gastrin (0.4 or 0.8 g/kg per hr) or histamine dihydrochloride (0....