OBJECTIVE We sought to determine the usefulness of the (99m)Tc-MIBI (MIBI) washout rate for the evaluation of steroid therapy in cardiac sarcoidosis (CS). METHODS Eleven CS patients underwent MIBI myocardial SPECT both before and 6 months after initiating steroid therapy. The washout rate (WOR) of MIBI was calculated using early and delayed polar map images. The washout score (WOS) of MIBI wa...

BACKGROUND Nephrotic syndrome occurs very rarely, in only about 0.01%-0.02% of all pregnancies, and de novo minimal change disease during pregnancy is especially rare. Nephrotic syndrome and, especially, minimal change disease are highly responsive to steroids, and preterm labor may be avoidable if the maternal condition is improved with steroid therapy. Therefore, prompt diagnosis and proper m...

pemphigus vulgaris (pv) is often complicated by osteoporosis. although corticosteroid therapy undoubtedly plays a causative role, inflammation associated with pv may also contribute to osteoporosis. this study was designed to determine the prevalence of osteoporosis in patients with pv before corticosteroid therapy and to compare these findings with those reported previously in healthy voluntee...

Glucocorticoids are often used as immunosuppressant and anti-inflammatory therapy in various medical conditions. In addition to providing clinical benefits, glucocorticoids have side effects, one of which is related steroid-induced diabetes mellitus (SIDM). Steroid-induced can be a new onset or an exacerbation hyperglycemia patients who previously been diagnosed with DM. Acute chronic due stero...

Results Seven female and 3 male patients with a mean age of 22.5±17.8 years and a mean diagnosis delay of 12.4 years were identified. Their clinical characteristics ranged from self resolving attacks of fever, urticaria and arthralgia to a chronic, debilitating steroid-dependent inflammatory disease. Splenomegaly, transfusion-dependent anemia, sensory neuropathy and pericarditis, manifestations...

This article presents a review of conservative therapies for plantar fasciitis pain reduction with a discussion of steroid therapy risks. The therapies reviewed include orthoses, stretching, extracorporeal shockwave, BTX-A, and corticosteroid injection/iontophoresis. These modes were included based on the availability of double blinded randomized controlled trials. We noted the following findin...

OBJECTIVE To assess the efficacy of levamisole in frequently relapsing nephrotic syndrome and steroid-dependent nephrotic syndrome. STUDY DESIGN Retrospective analysis of hospital case records. SETTING Pediatric nephrology department of a tertiary referral pediatric hospital. PARTICIPANTS 62 children with frequently relapsing nephrotic syndrome and 35 children with steroid-dependent nephr...

Objectives: To assess the cumulative response of very high dose steroids and sequentially added Vigabatrin in patients of infantile West Syndrome. Methods: This was an observational study conducted at a tertiary care hospital from August-2014 to August2015. Children aged 2-23 months presenting with infantile spasms with hypsarrhythmia on EEG were enrolled. The study participants were started on...

Case A-7 year old boy was admitted with complaints of edema on his eyelid and lower extremity. On admission, he had edema, hepatosplenomegaly, proteinuria and hypoalbuminemia. So his diagnosis was accepted as nephrotic syndrome and steroid therapy was started. Since he did not respond steroid therapy, kidney biopsy was performed. Biopsy findings were consistent with amyloidosis. Steroid therapy...

A patient under treatment for chronic lymphocytic leukaemia developed lobar pneumonia after 8 months. When antileukaemic therapy was discontinued, features of an ectopic ACTH syndrome developed, secondary to bronchogenic carcinoma. Exogenous steroid therapy for leukaemia seemed to suppress the clinical manifestations of the ectopic ACTH syndrome while subsequent endogenous steroid production co...