Background and Aim: The purpose of the present study is to provide a basis for use Curcuma longa extract as therapeutic agent status epilepticus. Methods: effect on epilepticus in rat model was investigated. rat’s SE induced by pilocarpine evaluated through measurement seizure duration, brain oedema hippocampal oxidative stress this model. Results: In pre-treated with (400mg/kg) water content l...

Status epilepticus (SE) is a frequent neurological emergency requiring immediate treatment. Therapy usually requires intravenous anticonvulsive medication. Lacosamide is a novel anticonvulsant drug that is available as infusion solution. We describe seven patients with focal SE who were treated with intravenous Lacosamide. All patients in our case series were unsuccessfully treated with other a...

BACKGROUND The "Status Epilepticus Severity Score" (STESS) is the most important clinical score to predict in-hospital mortality of patients with status epilepticus (SE), but its prognostic relevance for long-term survival is unknown. This study therefore examined if STESS and its components retain their prognostic relevance beyond acute treatment. METHODS One hundred twenty-five non-anoxic p...

Status epilepticus is defined as continuous seizure activity for greater than 5 minutes or consecutive seizures without regaining consciousness over 5 minutes. Status epilepticus is common in the epilepsy population and is often associated with acute, severe neurological injury or illness such as traumatic brain injury (TBI), intracerebral hemorrhage (ICH), meningitis, or pharmacologic toxicity...

Most of the information on predisposing factors and mortality in status epilepticus (SE) arises from data obtained from patients presenting to the casualty department. However, another population which is frequently seen by consultative neurologists are medically ill patients who develop SE while in hospital. These patients are often notoriously difficult to treat once SE arises. We sought to c...

The nuclear factor erythroid 2-related factor 2 pathway (Nrf2) has been previously identified to protect the brain against various impacts. Here, we investigated the effect of the Nrf2 activator sulforaphane in various seizure models and hippocampal mitochondrial bioenergetics. We found that daily injections of sulforaphane for 5 days elevated the seizure thresholds to 6 Hz stimulation and fluo...

BACKGROUND Two clinical scoring systems, the status epilepticus severity score (STESS) and the epidemiology-based mortality score in status epilepticus (EMSE), are used to predict mortality in patients with status epilepticus (SE). The aim of this study was to compare the outcome-prediction function of the two scoring systems regarding in-hospital mortality using a multicenter large cohort of a...

Las benzodiacepinas se usan para tratar la abstinencia alcohólica siguiendo varias estrategias: dosis descendiente, dosis de carga, tratamiento en función de sintomatología. La carga de diazepam ha demostrado ser un tratamiento válido para la abstinencia alcohólica en ensayos controlados aleatorizados. Tras una búsqueda bibliográfica no sistemática, no hemos encontrado antecedentes en la litera...

OBJECTIVE To learn the conceptions and actions of health professionals on the care network for women in situations of violence. METHOD A qualitative, descriptive, exploratory study was conducted between April and July 2015 with the participation of 21 health professionals from four primary health care teams in a city of the central region of the state of Rio Grande do Sul. Data were collected...

Se considera que una economı́a entra en recesión técnica cuando ha experimentado por dos trimestres consecutivos un crecimiento negativo del producto interior bruto (PIB). Las crisis económicas, con frecuencia precedidas por crisis financieras, aumentan el desempleo y el empobrecimiento de las familias. Los economistas estudian con gran atención la dinámica de los ciclos económicos desde que Kon...