BACKGROUND The aim of the present study was to describe the distribution of regional cerebral blood flow during the hypnotic state (HS) in humans, using positron-emission tomography (PET) and statistical parametric mapping. METHODS The hypnotic state relied on revivification of pleasant autobiographical memories and was compared to imaging autobiographical material in "normal alertness." A gr...

A simulation study was conducted to address the issue of how purely additive (simple) genetic architecture might impact on the efficacy of parametric and non-parametric genomic prediction methods. For this purpose, we simulated a trait with narrow sense heritability h2= 0.3, with only additive genetic effects for 300 loci in order to compare the predictive ability of 14 more practically used ge...

One of the interesting topics on multimedia domain is concerned with empowering computer in order to speech production. Speech synthesis is granting human abilities to the computer for speech production. Data-based approach and process-based approach are the two main approaches on speech synthesis. Each approach has its varied challenges. Unit-selection speech synthesis and statistical parametr...

Dynamic causal modeling (DCM) is a recently developed approach for effective connectivity measurement in the brain. It has attracted considerable attention in recent years and quite widespread used to investigate brain connectivity in response to different tasks as well as auditory, visual, and somatosensory stimulation. This method uses complex algorithms, and currently the only implementation...

Schizophrenia is associated with widespread and complex cerebral blood flow (CBF) disturbance. Auditory verbal hallucinations (AVH) and insight are the core symptoms of schizophrenia. However, to the best of our knowledge, very few studies have assessed the CBF characteristics of the AVH suffered by schizophrenic patients with and without insight. Based on our previous findings, Using a 3D pseu...

OBJECTIVE This [11C]flumazenil (FMZ) study evaluates the performance of various parametric analysis methods and their ability to detect statistically significant group differences. METHODS Dynamic 60-min FMZ scans were performed in eight healthy and nine individuals with major depressive disorder. Parametric volume of distribution (VT) images were generated using a basis function method (BFM)...

Nonhomogeneous Poisson processes (NHPPs) are often used to model recurrent events, and there is thus a need to check model fit for such models. We study the problem of obtaining exact goodness-of-fit tests for certain parametric NHPPs, using a method based on Monte Carlo simulation conditional on sufficient statistics. A closely related way of obtaining exact confidence intervals in parametri...

In this paper we present a general multivariate approach to the analysis of functional imaging studies. This analysis uses standard multivariate techniques to make statistical inferences about activation effects and to describe the important features of these effects. More specifically, the proposed analysis uses multivariate analysis of covariance (ManCova) with Wilk's lambda to test for speci...