Purpose Early phase I study of safety of AXL1717 in patients with recurrent or progressive malignant astrocytomas and evaluation of preliminary anti-tumor efficacy. Patients and methods Nine patients fulfilling the set criteria were enrolled. Eight had recurrent glioblastoma and one gliosarcoma. Patients were treated with an oral suspension of AXL1717 (215-400 mg bid) cycle-by-cycle in 35-day...

We show that transverse perturbations from structurally stable heteroclinic cycles can be destabilized by surprisingly small amounts of noise, even when each individual fixed point of the cycle is stable to transverse modes. A condition that favours this process is that the linearization of the dynamics in the transverse direction be characterized by a non-normal matrix. The phenomenon is illus...

A new homology is defined for a non-self-adjoint operator algebra with a distinguished masa which is based upon cycles and boundaries associated with complexes of partial isometries in the stable algebra. Under natural hypotheses the zeroth order group coincides with the K0 group of the generated C ∗-algebra. Several identifications and applications are given, and in particular it is shown how ...

A layer structured K-doped (NH4)2V3O8/graphene (K-NVG) was prepared via a hydrothermal route and then used as an anode material for sodium-ion batteries for the first time. The K-NVG nanosheets have a diameter in the range of 200-500 nm. The K-NVG electrode exhibited stable cycling and a good rate performance with a reversible capacity of 235.4 mA h g(-1), which is much higher than the 90.5 mA ...

We study the global dynamics of integrate and fire neural networks composed of an arbitrary number of identical neurons interacting by inhibition and excitation. We prove that if the interactions are strong enough, then the support of the stable asymptotic dynamics consists of limit cycles. We also find sufficient conditions for the synchronization of networks containing excitatory neurons. The...

In an exchange economy with a finite number of indivisible goods, we analyze a dynamic trading process of coalitional recontracting where agents may make mistakes with small probability. We show first that the recurrent classes of the unperturbed (mistakefree) process consist of (i) all core allocations as absorbing states, and (ii) cycles of non-core allocations. Next, we introduce a perturbed...

This paper develops the concept of reduction-based control, which is founded on a controlled form of geometric reduction known as functional Routhian reduction. We prove a geometric property of general serial-chain robots termed recursive cyclicity, identifying the inherent robot symmetries that we exploit with the Subrobot Theorem. This shows that any serial-chain robot can be decomposed for a...

This paper is concerned with the passive walking of an underactuated biped robot. First, we present the modelling of the biped robot (that is a 7 DOF robot). Then, we focus on the study of the almost passive dynamic walking. In particular, we show that the application of a nonlinear feedback control to stabilize the torso and knees leads the biped robot to perform a stable almost-passive dynami...

In an exchange economy with a finite number of indivisible goods, we analyze a dynamic trading process of coalitional recontracting where agents may make mistakes with small probability. We show first that the recurrent classes of the unperturbed (mistakefree) process consist of (i) all core allocations as absorbing states, and (ii) cycles of non-core allocations. Next, we introduce a perturbed...

The failure of the Ge2Sb2Te5 (GST) phase change memory cell has been investigated by the High Resolution Transmission Electron Microscopy (HR-TEM). The HR-TEM results indicate that the both of hexagonal structured GeSbTe (GST) and meta stable GeTe phases are appeared after about 10 cycles of set/reset operations. The face centered cubic structured GST seems to be quickly changed from amorphous ...