Article history: Received on: 31/01/2016 Revised on: 16/03/2016 Accepted on: 14/04/2016 Available online: 28/06/2016 A simple, highly sensitive stability indicating reverse phase high-performance liquid chromatographic (RPHPLC) method was developed and validated for the determination of sumatriptan succinate in bulk and tablet dosage form. The analysis was performed on reverse phase C18 ODS Ine...

A simple, sensitive, rapid, cheap and reliable UV spectrophotometric method for the quantitative determination of cefoxitin in powder for injection dosage form has been developed. The UV-spectrum has scanned between 200 nm and 400 nm, and 231 nm is selected as maximum wavelength for absorption. This method obeys Beer’s law in the range of 10 – 50 μg/mL with correlation coefficient of 0.999. The...

A precise and feasible high-performance liquid chromatographic (HPLC) method for the analysis of antiemetic drug Ondansetron tablet dosage form has been developed. The analysis was carried out on a zodiac C18 (4.6 x 250mm, 5 mm) column, using a buffer (pH 2.2), acetonitrile (73:27) as the mobile phase using a low pressure gradient mode with flow rate at 1ml/min and analysis was performed at wav...

A sensitive, selective, precise and stability indicating a high-performance thin layer chromatographic method for the analysis of rufinamide (Rf) in bulk drug and its formulations was developed and validated. The method employed thin layer chromatography aluminum plates precoated with silica gel 60 F254 as the stationary phase. The solvent system consisted of chloroform : methanol : glacial ace...

An ultra-fast liquid chromatographic method and two UV spectroscopic methods were developed for the determination of cephalexin monohydrate in pharmaceutical dosage forms. Isocratic separation was performed on an Enable C18G column (250 mm × 4.6 mm i.d., 5 μm) using methanol:0.01 M TBAHS (50:50, v/v) as the mobile phase at a flow rate of 1.0 ml/min. The PDA detection wavelength was set at 254 n...

A simple, precise and rapid stability-indicating ultra-performance liquid chromatography (UPLC) method was developed for the simultaneous quantitative determination of Olmesartan, Amlodipine and Hydrochlorothiazide from their innovative Pharmaceutical combination drug product, with the presence of degradation products. It involved a 50 mm × 2.1 mm, 1.8 μm Phenyl column. The separation was achie...

The present work reports a stability indicating reversed phase ultra performance liquid chromatography (RP-UPLC) method for the quantitative determination of quetiapine in pharmaceutical dosage form. The chromatographic separation is performed on an Agilent Eclipse Plus C18, RRHD 1.8 μm (50 mm x 2.1 mm) column using gradient elution. The optimized mobile phase consists of 0.1 % aqueous triethyl...

BACKGROUND A new, simple, selective, precise, and stability-indicating high-performance thin-layer chromatographic method has been established for analysis of itraconazole (ITZ) in the bulk drug and in pharmaceutical formulations. Separation was achieved on aluminium plate precoated with silica gel 60F254 using Toluene : Chloroform : Methanol [5: 5: 1.5(v/v)] as mobile phase. Densitometric anal...

A novel stability-indicating LC assay method was developed and validated for quantitative determination of epinastine in bulk drugs and in pharmaceutical dosage form in the presence of degradation products generated from forced degradation studies. An isocratic, reversed phase LC method was developed to separate the drug from the degradation products, using an YMC ODS AC18 (250 mm x 4.6 mm, 5 μ...