The 2009-10 Argus Commission was charged to examine the topic of the pharmacist’s contribution to primary healthcare delivery in the context of national healthcare reform and identify the resources of the Academy and the profession needed to engage in the national conversation. The charge further requested the Argus Commission to scan the environment to determine the opportunities for expansion...

BACKGROUND AND AIMS Cachexia is a syndrome characterized by marked involuntary loss of body weight. Recently, adipose tissue (AT) wasting has been shown to occur before the appearance of other classical cachexia markers. We investigated the composition and rearrangement of the extracellular matrix, adipocyte morphology and inflammation in the subcutaneous AT (scAT) pad of gastrointestinal cance...

Mitochondrial dysfunction is a potentially important player in the development of insulin resistance and type 2 diabetes mellitus (T2DM). We investigated the changes of mRNA expression of genes encoding main enzymatic complexes of mitochondrial respiratory chain in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM) of 11 subjects with simple obesity (OB), 16 obese patients with T2...

We describe and evaluate WatchTower, a system that simplifies the collection of Windows performance counter data, and Argus, a statistical methodology for evaluating this data and reducing the sheer volume of it. This is especially important when monitoring the performance of clusters for high performance computing. WatchTower’s overheads are comparable to those of Microsoft’s perfmon tool, whi...

We propose ARGUS, a high density, low power supercomputer built from an IXIA network analyzer chassis and load modules. The prototype is a diskless MPP scalable to 128 processors in a single 9U chassis. The entire system has a footprint of 1/4 meter2 (2.5 ft2), a volume of 0.09 meter3 (3.3 ft3) and maximum power consumption of less than 2200 watts. We compare and contrast the characteristics of...

Efficiency in Your Safety Operations with Oracle Argus A Complete Solution for Clinical and Post-Marketing Safety A constantly evolving regulatory climate worldwide, the critical focus on understanding the risk/benefit profile of products through all phases of development, increasingly complex and global clinical trials, and shrinking R&D resources have all fueled new demands for more efficient...

Protein recycling is important for maintaining homeostasis of the Golgi and its cisternae. The Vps54 (Scat) protein, a subunit of the GARP tethering complex, is a central factor in retrograde transport to the trans-Golgi. We found the scat(1) mutant to be male sterile in Drosophila with individualization problems occurring during spermatogenesis. Another typically observed phenotype was the abn...

The 2008-09 Argus Commission was charged to examine the question of how colleges and schools of pharmacy are working to create agents of change for pharmacy and society. This charge was derived from the recommendation of the 2007-08 Argus Commission which stated that “the 2008-09 Commission, collaboratively with national student pharmacy leaders, should examine the curricular, co-curricular and...

The use of pure heavy hydrocarbons like propane or isobutane has some advantages for drift chaders that measure the specific ionisation for particle identification. With a prototype of the ARGUS drift chamber various gases were tested with a 3 GeV/c electron beam. We found a dE/dx resolution for propane of Fwhm= 10.4% and for isobutane Fwhm = 9.9X, by a factor of + 1.6 better than that for argo...