BACKGROUND In Egypt, breast cancer ranks number one among the female malignancies. Activation of oncogenes and inactivation of tumor suppressor genes are thought to play an important role in the development and progression of breast cancer. PURPOSE The present study is a trial to investigate the role of chromosome 17 in sporadic invasive ductal carcinoma of the breast through detection of LOH...

Tumor formation results from alterations in the normal control of cell proliferation. In the past decade, much attention in cancer research has been focused on the function of proto-oncogenes and tumor suppressors. Prohibitin is a potential tumor suppressor which was originally identified because of its anti-proliferative activities. Subsequent investigations led to the discovery of prohibitin ...

Materials and Methods Linkage analysis in familial breast and ovarian cancer and studies of Tissue Samples and DNA Extraction. OvarÃ-an tumor tissue samples were allelic deletion in sporadic ovarian tumors have suggested that chromo some 17q may be the location of a gene of importance in ovarian cardilogenesis. We have examined tumor and normal DNA samples from 120 patients with ovarian tumors ...

There has been little improvement in the prognosis for adolescent and young adult (AYA) tumor patients. Hence, there is an urgent need to understand the etiology of tumor development and identify actionable gene aberrations to improve prevention and therapy. Here, 76 sporadic tumors (48 breast, 22 ovarian, and six uterine) from 76 AYA females (age range, 25-39 years) were subjected to whole exo...

background : breast cancer is the most common invasive cancer in females worldwide. it accounts for 16% of all female cancers and 22.9% of invasive cancers in women. 18.2% of all cancer deaths worldwide including both males and females are from breast cancer. in this study we compared few serum elements in patients with benign and malignant breast tumor to find any related prognostic and predic...

the p21 belongs to the cip/kip family of cdk inhibitors involved in cell cycle arrest at specific stages of the cell cycle progression. dna methylation is the best studied epigenetic mark that have been evidently associated to chromatin condensation, and repression of gene transcription. the cpg island hypermethylation in promoter region of certain genes occurs in cancer cells and affects tumor...

Breast cancer is a malignant tumor and the most common cancer among American women that starts from cells of the breast. The growth of the size of data exceeds the ability of humans to analyze the data. So we need some intelligent machines that can analyze datasets intelligently for us. We propose a Multi Nominal Logit Model to evaluate correlation between risk factors of breast tumor. Our ...

Granular cell tumor is a rare benign non-encapsulated tumor that mostly presents in oral cavity. Breast localization is uncommon and occurs in about one per 1000 cases of breast cancers. It mainly affects premenopausal women showing the possible role of estrogen and progesterone levels in the progression of this tumor. Granular cell tumor is a great emulator of the invasive ductal carcinoma of ...