PURPOSE: To establish the methods of semi-quantification of regional hepatic blood flow using paramagnetic iron oxide (SPIO)-enhanced dynamic MR imaging and two-input, one-compartment model in phantom and clinical studies. METHOD AND MATERIALS: The phantom study was conducted using a 1.5-T MR scanner (Achieva, Philips Medical Systems) and SPIO (Resovist, Bayer Healthcare)-agarose phantom. 2D-GR...

OBJECTIVE To evaluate clinical 3.0T magnetic resonance for tracking and quantifying superparamagnetic iron oxide (SPIO)-labeled endothelial progenitor cells (EPCs) in vitro and homing to liver with acute injury in vivo. METHODS The bone marrow-derived EPCs were isolated and cultured for 4 days and examined in vitro for lineage markers. Then the cultured cells were labeled with a ferumoxides-p...

Introduction: Early detection of HCC is important in improving patient outcome and decision making in therapeutic strategies. Many authors reported superparamagnetic iron oxide (SPIO) enhanced magnetic resonance imaging (MRI) is effective for the differentiation of benign and malignant hepatic lesions and the percentage of signal intensity loss (PSIL) might reflect Kupffer-cell numbers in tumor...

Introduction At 3.0 T MR system, superparamagnetic iron oxide (SPIO)-enhanced liver magnetic resonance imaging (MRI) may have the theoretical advantage of high SNR and high liver to lesion contrast, because of stronger susceptibility effect compared with that at 1.5 T. On T2*-weighted gradient recalled echo (GRE) sequences essential for SPIO-enhanced liver MRI, positive effects of 3T on lesion-...

BACKGROUND (19)F magnetic resonance imaging (MRI) was recently introduced as a promising technique for in vivo cell tracking. In the present study we compared (19)F MRI with iron-enhanced MRI in mice with photothrombosis (PT) at 7 Tesla. PT represents a model of focal cerebral ischemia exhibiting acute vessel occlusion and delayed neuroinflammation. METHODS/PRINCIPAL FINDINGS Perfluorocarbons...

Introduction: Quantitative susceptibility mapping (QSM) is a technique that uses phase data from an MRI image to estimate the susceptibility distribution in the object. It has been demonstrated that QSM is able to correctly estimate the magnetic moment of specimen differing in susceptibility to the surrounding tissue [1]. We would like to exploit this ability to perform quantitative imaging of ...

introduction: apoptosis is a major consequence of ionizing radiation in proliferative tissues and quantification of the apoptotic cells could be helpful for noninvasive assessment and estimation of the radiation absorbed dose. annexin v conjugated with super paramagnetic iron oxide nanoparticles (anx-spio) is a biological probe for detection of apoptotic cells using magnetic resonance imaging. ...

Background Myocardial infarction (MI) leads to cardiomyopathy through a combination of programmed cell death (re: apoptosis) and necrotic cell death. The relative contribution of apoptosis to ischemic cardiomyopathy and the effect of targeting apoptosis specifically to prevent MIinduced damage is unknown. Our laboratory previously developed and validated an in vivo, MRI-detectable apoptosis pro...