introduction: endothelial progenitor colony forming unit-endothelial cells (cfu-ec) were first believed to be the progenitors of endothelial cells, named endothelial progenitor cells. further studies revealed that they are monocytes regulating vasculogenesis. the main hindrance of these cells for therapeutic purposes is their low frequency and limited replicative potentials. this study was unde...

background: wound healing of burned skin remains a major goal in public health. previous reports showed that the bone marrow stem cells were potent in keratinization and vascularization of full thickness skin wounds. methods: in this study, mesenchymal stem cells were derived from rat adipose tissues and characterized by flowcytometry. staining methods were used to evaluate their differentiatio...

there are two main methods for preparing the puramatrix (pm) as a three-dimensional (3-d) scaffold for supporting the cells including surface plating and encapsulation. in the surface-plating procedure, the scaffold is created by adding an ionic agent such as medium to pm. after adjusting the ph by changing the medium, cells are seeded on top of the scaffold. in the encapsulation method, pm and...

perivascular epithelioid cell tumor (pecoma) is composed of hmb45+ epithelioid cells with clear to granular cytoplasm and perivascular distribution. we describe a uterine pecoma in a 33 years old woman where tumor cells were positive for hmb45 but negative for epithelial markers and negative or positive for smooth muscles markers.

objective(s) the use of co-culture cells as well as extra cellular matrix are among those strategies that have been employed to direct mesenchymal stem cell (msc) bone differentiation in culture. in this regard, there is no study considering the effects of matrigel on mesenchymal stem cell (msc) in vitro bone differentiation. this was the subject of the present study. materials and methods huma...

objective(s)  garlic (allium sativum) is known as a potent spice and a medicine with broad therapeutic properties ranging from antibacterial to anticancer, and anticoagulant. one of the major purified garlic protein components is the 47 kda protein. in this study, the effect of 47 kda protein extracted from aged garlic (age) was evaluated on mouse dendritic cell (dc) maturation in vitro. materi...

interleukin-4 (il-4) is produced by t-helper cells type 2 (th2) and induces ige synthesis. t-helper cells type 1 (th1) produce interferon-gamma (ifn-gamma) which suppresses th2 and reduces il-4 induced ige production. in this :;tudy , we demonstrated that the levels of specific ige in the serum of atopic children (n=20) were elevated while il-4 production was increased and ifn-gamma secretion w...

mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. peroxisome proliferator-activated receptor gamma (pparγ) is a member of the large nuclear hormone  receptor  transcription  factor  superfamily, and  has  been  recently implicated in the anti-inflammatory response. to investigate a possible role for pparγ in human mast cells, we studied the ...

traumatic brain injury (tbi) is defined as an external mechanical injury to the brain. neuroinflammation plays a vital role in the pathophysiology of tbi. microglia and astrocytes play a central role in the initiation and regulation of inflammation. numerous pro-inflammatory mediators including cytokines, chemokines, reactive oxygen species (ros) and nitric oxide (no) released by microglia. in ...