Abstract Sonodynamic therapy is a minimally invasive high-intensity focused ultrasound (HIFU) based that combines sonosensitizer and reactive oxygen species (ROS), which are produced by acoustic cavitation. In this paper, we experimentally examined the effectiveness of proposed method scanning focus in direction HIFU propagation for continuously generating cavitation clouds to expand region ROS...

Low frequency ultrasound in the 20 to 60 kHz range is a novel physical modality by which to induce selective cell lysis and death in neoplastic cells. In addition, this method can be used in combination with specialized agents known as sonosensitizers to increase the extent of preferential damage exerted by ultrasound against neoplastic cells, an approach referred to as sonodynamic therapy (SDT...

Sonodynamic therapy (SDT) was developed as a promising noninvasive approach. The present study investigated the antitumor effect of a new sensitizer (sinoporphyrin sodium, referred to as DVDMS) combined with multiple ultrasound treatments on sarcoma 180 both in vitro and in vivo. The combined treatment significantly suppressed cell viability, potentiated apoptosis, and markedly inhibited angiog...

PURPOSE To investigate the sonoactivity of hypericin (HY), together with its sonodynamic effect on THP-1 macrophages and the underlying mechanism. MATERIALS AND METHODS CCK-8 was used to examine cell viability. Confocal laser scanning microscopy was performed to assess the localization of HY in cells, reactive oxygen species (ROS) generation, and opening of the mitochondrial permeability tran...

Sonodynamic therapy (SDT) has stronger penetrating ability compared with phototherapy due to the replacement of excitant from near-infrared light ultrasound. The effective combination low-intensity ultrasound and sonosensitizers allows SDT penetrate deep tissue for treatment solid tumors. In this research, hybrid metal-organic framework (MOF) nanoparticles (FcCOOH-ZnTCPP, FcCOOH: ferrocenecarbo...