Nesfatin-1, a newly discovered satiety molecule, is located in the hypothalamic nuclei, including the paraventricular nucleus (PVN) and supraoptic nucleus (SON). In this study, fine localization and regulation of nesfatin-1 neurons in the PVN and SON were investigated by immunohistochemistry of neuropeptides and c-Fos. In the PVN, 24% of nesfatin-1 neurons overlapped with oxytocin, 18% with vas...

G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors in the mammalian genome. They are activated by a multitude of different ligands that elicit rapid intracellular responses to regulate cell function. Unsurprisingly, a large proportion of therapeutic agents target these receptors. The paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamu...

Topographic maps are salient features of neuronal organization in sensory systems. Inhibitory components of neuronal circuitry are often embedded within this organization, making them difficult to isolate experimentally. The auditory system provides opportunities to study the topographic organization of inhibitory long-range projection nuclei, such as the superior olivary nucleus (SON). We anal...

It’s a Boy! Women and Non-Monetary Benefits from a Son in India Son preference is widespread in a number of developing countries. Anecdotal evidence suggests that women may contribute to the persistence of this phenomenon because they derive substantial long-run non-monetary benefits from giving birth to a son in the form of an improvement in their intra-household position. This paper tests thi...

Network security is considered one of the obstacles that prevent the wide deployment of ad-hoc wireless networks. Among many security problems, authentication is the most fundamental problem that has to be solved before any others. Some previous solutions requiring centralized entities were not scalable and others requiring physical encounter took a long time. We propose a new architecture, cal...

Oxytocin (OT) is one of the neuropituitary hormones and is synthesized in the neurons of the paraventricular nucleus (PVN) and supraoptic nucleus (SON). Previous studies have shown that the mRNAs encoding OT are delivered from the soma to both dendrites and axons of the neurons in the PVN and SON. However, it has not been elucidated whether a translational regulation mechanism to enable local s...

In this report we have tried to explain the reasons behind the difference in the pattern of transfusion requirement between two members of a family with similar β-globin mutation. The father and younger son both are HbE-β, but the father never had transfusion, whereas the younger son takes transfusion monthly. Mother and the elder son are HbEE without any history of transfusion. β-globin mutati...

Empirical evidence suggests that parents who have themselves inherited from their own parents are more likely to leave an estate to their children even after controlling for income, wealth and education. This implies an indirect reciprocal behavior between three generations by transmitting the attitude towards bequeathing from one generation to the next. We incorporate such an intergenerational...

A father and son presented ten years apart with a fourth ventricle ependymoma. The history, imaging and pathology are presented and the aetiology of familial ependymoma discussed.

according adhar bigdili, muhammad ali was son of abdal biq naqqashbashi (painter laureate)and grandson of aliquli biq jabadar, court painter of shah safi and shah abbas ii safawi. adhar bigdili credited muhammad ali with naqqashbashi of shah tahmasp ii safawi and nadir shah afshar. having learnt the art of painting from his father, muhamma ali in turn trained ali ashraf, who worked under patron...