The effect of contaminants on the genomes of Chironomus plumosus L. and Chironomus bernensis Wülker, Klötzli species was studied in the Dunajec River (station 1) and in the littoral of Czorsztyn Reservoir (stations 2 and 3). According to the index of geoaccumulation, the sediments were polluted by cadmium (Cd) and chromium (Cr). Cd concentrations at stations 1, 2, and 3 were 0.71, 0.56, and 1.2...

Human molecular cytogenetics integrates the knowledge on chromosome and genome organization at the molecular and cellular levels in health and disease. Molecular cytogenetic diagnosis is an integral part of current genomic medicine and is the standard of care in medical genetics and cytogenetics, reproductive medicine, pediatrics, neuropsychiatry and oncology. Regardless numerous advances in th...

Dosage compensation in mammals occurs by X inactivation, a silencing mechanism regulated in cis by the X inactivation center (Xic). In response to developmental cues, the Xic orchestrates events of X inactivation, including chromosome counting and choice, initiation, spread, and establishment of silencing. It remains unclear what elements make up the Xic. We previously showed that the Xic is co...

‘Niagara Steck’ and Variegada’ are two grapevine varieties that arose spontaneously as somatic mutants of Rosada’. Berries characterize at young stages exhibiting a remarkable brown reticulated structure on the epidermis which develops into brown-bronze russet-like berries ripe. The mature have strongly acidic flesh. shows notable variegation in leaves berries. Meiotic studies were carried out ...

Somatic transposition in mammals and insects could increase cellular diversity and neural mobilization has been implicated in age-dependent decline. To understand the impact of transposition in somatic cells it is essential to reliably measure the frequency and map locations of new insertions. Here we identified thousands of putative somatic transposon insertions in neurons from individual Dros...

Abstract The X-chromosome linked RNA helicase DDX3X plays multiple roles in metabolism and antiviral interferon responses. Some viruses, including SARS-CoV-2, usurp the function of to support viral genome replication evasion interferon. These findings have led development inhibitors as potential agents. However, somatic loss mutations this are neurological disease malignancies, a form non-Hodgk...

Centrosomes are thought to ensure spindle bipolarity and thus correct chromosome segregation during mitosis, but recent studies indicate that somatic cells have an alternative mechanism that enables them to form a bipolar spindle and segregate chromosomes independently of centrosomes.

SOURCE AND DESCRIPTION OF CLONE: A 1.65 kb ECORI cDNA insert corresponding to the full length hepatic lipase (HL) sequence isolated from a rat liver cDNA library (I). CHROMOSOMAL LOCALIZATION: Chromosome 15q21 by somatic cell and in situ hybridization (2).

We have proposed a hypothetical model to explain the role of chromosomal aberrations in malignant development. In this model we postulate two kinds of chromosomal changes: (1) primary, active changes caused by direct inter action between the oncogenic agent and the hereditary material of the host cello These changes are mainly somatic mutations, but mayaIso be associated with directed structura...

Coincidence. . . . . . . . . . . . .............................. 54 Non-disjunction . . . . . . . . .............................. 55 Gynandromorphs. . . . . . . ............................... 55 Absence of gynandromorp s hybrids.. .................... 60 Somatic mutations, . . . . . ................................... 61 SUMVARY.. ................................................................