The control of primary and further structures of individual folded/collapsed synthetic polymers has received significant attention in recent years. However, the synthesis of single-chain nanoparticles (SCNPs) showing a compact, globular conformation in solution has turned out so far to be highly elusive. By means of simulations, we propose two methods for obtaining globular SCNPs in solution. T...

Mass spectrometry can be used to characterize multiprotein complexes, defining their subunit stoichiometry and composition following solution disruption and collision-induced dissociation (CID). While CID of protein complexes in the gas phase typically results in the dissociation of unfolded subunits, a second atypical route is possible wherein compact subunits or subcomplexes are ejected witho...

In order to satisfy with the individual and various demand of customer, the present study is focused on the Min-Max Vehicle Routing Problem (MMVRP). According to the characteristics of model, new tabu search algorithm is used to get the optimization solution. It applies newly improved insertion method to construct initial solution, to improve the feasibility of the solution; centers the longest...

The theory of bargaining as formulated by Nash (1950, 1953) has developed along two routes. One is axiomatic (e.g., Nash 1950; Kalai and Smorodinsky 1975; Roemer 1988). Here, the negotiation process underlying the bargaining is only implicit. The idea is to try to characterize the negotiated outcome (the solution) through a set of axioms without formally modeling the process. The advantages of ...

Transport xenobiotis throug tissues and organs was studied. The aim of this paper dynamic xenobiotic transfer and accumulation in the specific tissues and organs were investigated. Some of xenobiotics are suficiently soluble in blood to account for simple solution as a route of distribution. Many xenobiotics are distributed in association which plasma proteins. Cellular components are responsib...

This paper describes a route construction method for the vehicle routing problem with multiple vehicle types and time window constraints. Several insertion-based savings heuristics are presented. The heuristics were tested on twenty-four 100-customer problems modified from the literature. Experimental results demonstrate that heuristics with the consideration of a sequential route construction ...

In this note we consider the Shabal permutation function P as a block cipher with input Ap,Bp and key C,M and describe a distinguisher with a data complexity of 2 random inputs with a given difference. If the attacker can control one chosen bit of Bp, only 2 21 inputs with a given difference are required on average. This distinguisher does not appear to lead directly to an attack on the full Sh...