Continuous administration of soluble proteins, delivered over a 10-d period by a mini-osmotic pump implanted subcutaneously, induces a long-lasting inhibition of antigen-specific T cell proliferation in lymph node cells from BALB/c mice subsequently primed with antigen in adjuvant. The decreased T cell proliferative response is associated with a down-regulation of the T helper cell (Th)1 cytoki...

the hepatitis b surface antigen ( hbsag) gene was isolated from an iranian hbeag positive carrier by pcr. the gene was cloned in puc19 for sequencing and pyes2 for expression in saccharomyces cerevisiae, which pnf1 and pdf3 constructs were made respectively. the sequencing data showed that the isolated hbsag gene shared more than 90% homology with the ayw subtype. the pdf3 was transferred into ...

Serological study of cell membrane antigens in the mouse has revealed several isoanfigenic systems demonstrable by cytotoxic isoantisera. Four of these systems of antigens are exclusively or predominantly represented on thymocytes. One of these, TL (thymus-leukemia) (1), is exclusively represented on thymocytes: two (Ly-A and Ly-B) have predominant representation on thymocytes and are present a...

individual preparation of two human t-cell lymphotropic virus type i (htlv-i) diagnostic gst fused peptides (mta-1 and gd21) is time-consuming and expensive. the aim of this study was to design a novel single chimeric antigen (sca) to obviate separate expression of proteins and reduce the cost of reagent preparation.structural protein fragments, including immunodominant b cell linear epitopes, ...