Diagnosis is essential for the management and treatment of patients with rare diseases. In a group patients, genetic study identifies variants uncertain significance or inconsistent phenotype; therefore, it urgent to develop novel strategies reach definitive diagnosis. Herein, we in-house Translational Diagnostics Program (TDP) validate as part diagnostic process close collaboration physicians,...

The genus Heterodera consists of 80 valid species which are distributed all over the world and they range from mono to polyphagous (Subotin et al., 2010). Several species are considered economically important (or quarantine), including H. humuli Filipjev, 1934. Previous studies on H. humuli or H. humuli as a vector of plant viruses were focused on its geographical distribution, biology, life cy...

Conflict of interest: Dr Jaffe presently receives research support and/or consults from Beckman Coulter, Critical Diagnostics, Inverness Medical, Ortho Clinical Diagnostics, Pfizer, Siemens Medical, and Tethys Bioscience. Dr Ordonez-Llanos presently receives support for research from Abbott Diagnostics, Inverness Medical, Roche Diagnostics and Siemens Medical among the companies which products ...