Anticancer drug development from natural resources are ventured throughout the world. Animal venoms and toxins a potential bio resource and a therapeutic tool were known to man for centuries through folk and traditional knowledge. The biodiversity of venoms and toxins made it a unique source of leads and structural templates from which new therapeutic agents may be developed. Venoms of several ...

In this study, venoms from species in the Colubrinae, Homalopsinae, Natricinae, Pseudoxyrhophiinae and Psammophiinae snake families were assayed for activity in the chick biventer cervicis skeletal nerve muscle preparation. Boiga dendrophila, Boiga cynodon, Boiga dendrophila gemincincta, Boiga drapiezii, Boiga irregularis, Boiga nigriceps and Telescopus dhara venoms (10 microg/ml) displayed pos...

Accelerated evolution of toxins is a unique feature of venoms, with the toxins evolving via the birth-and-death mode of molecular evolution. The venoms of sea snakes, however, are remarkably simple in comparison to those of land snakes, which contain highly complex venoms. Aipysurus eydouxii (Marbled sea snake) is a particularly unique sea snake, feeding exclusively upon fish eggs. Secondary to...

Objectives: The present study focuses on development of novel Metal-Herbal Nano composite (MHNC) formulation against Naja naja and Bungarus Caeruleus venoms animal models. Methods: were procured from Irula snake catchers society in lyophilised forms. Herbal-metal nanocomposites prepared 1:1 combinations. Single strength concentration Leucas zeylanica extracts copper oxide metal nanoparticles wa...

during the journey to India. I have now received specimens of the serum on two occasions, and find that they possess a well-marked power of neutralising cobra venom, the last received specimens being especially active. I do not propose on the present occasion to go into the details of my experiments. I may, however, briefly mention a semi-practical application that I have been able to make of P...

1. It has been shown that a number of proteolytic enzymes and snake venom, in relatively small amounts, and within a wide range of pH variation, will restore hyaluronidase activity after its inhibition by serum. 2. The known properties of the venom protease are found to be identical with those of Haas' "proinvasin I." It is concluded that the protease of the venom offers adequate explanation fo...

Although the resistance of snakes to their own venom is well known, until now no investigators have examined the serum of Australian snakes. Here we describe the identification and purification of a range of phospholipase A(2) (PLA(2)) inhibitors from the serum of Australian elapids. All PLA(2) inhibitors were composed of two protein chains, an alpha-chain and a beta-chain. The alpha-chains wer...

Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at increasing antivenom production and accessibility, is being promoted by the World Health Organization and others. This work discusses several aspects of antivenom manufacture and control in which the proteomic analysis ...