A new regulatory loop in cancer-cell invasion the epithelial-to-mesenchymal transition (EMt) converts epithelial cells into mesenchymal cells that are able to invade and migrate. in the context of cancer pathogenesis, the EMt contributes to meta-static progression (thiery, 2002; acloque et al, 2008). one of the characteristics of EMt is the functional loss of E-cadherin, which is crucial for th...

MicroRNAs (miRs) are short non-coding single stranded RNAs regulating the translation of target mRNAs in normal and cancer cells in which they are frequently dysregulated promoting tumor progression. Cancer stem cells (CSCs) of head and neck squamous cell carcinoma (HNSCC), identified by aldehyde-dehydrogenase expression (ALDH), are a cell subset within the tumor cell population that takes part...

Neural crest progenitor cells are the main contributors to craniofacial cartilage and connective tissue of the vertebrate head. These progenitor cells also give rise to the pigment, neuronal and glial cell lineages. To study the molecular basis of neural crest differentiation, we have cloned the gene disrupted in the mont blanc (mob(m610)) mutation, which affects all neural crest derivatives. U...