In response to DNA damage, cells arrest progression through the cell cycle at either G(1), S, or G(2). We have reported that UCN-01 (7-hydroxystaurosporine) abrogates DNA damage-induced S and G(2) arrest and enhances cytotoxicity selectively in p53 mutant cells, thus providing a potential, tumor-targeted therapy. Unfortunately, UCN-01 binds avidly to human plasma proteins, limiting bioavailabil...

Background: The epidermal growth factor receptor (EGFR) plays a key role in the and survival of many human tumors epithelial origin. monoclonal antibody, 40H3, targeting overexpressed EGFR truncated form variant III (EGFRvIII) on tumor cells, was conjugated to small molecules with potent cytotoxic activity, generating five antibody-drug conjugates (ADCs). Their lethality for cells evaluated vit...

We studied the cytotoxicity, cellular accumulation, and DNA interac tions induced by liposome-entrapped NDDP (L-NDDP) and cisplatin in A2780 human ovarian carcinoma cells sensitive (A2780/S) and resistant (A2780/PDD) to cisplatin. L-NDDP was 2-fold more cytotoxic than cis platin against A2780/S cells with 5-h or 24-h drug exposure. Both cell lines were equally sensitive to L-NDDP, while A2780/P...

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. Distal recurrences represent the dominant problem with this disease. Adjuvant chemotherapy has an established benefit but the administration of highly effective chemotherapy regimens has proven difficult. In their manuscript, Barbara Jonchere and colleagues used different colon cancer cell lines with the aim to unveil novel m...

Gastrointestinal mucositis is a debilitating side effect of chemotherapy treatment, with currently no treatment available. As changes in microbial composition have been reported upon chemotherapy treatment in vivo, it is thought that gut microbiota dysbiosis contribute to the mucositis etiology. Yet it is not known whether chemotherapeutics directly cause microbial dysbiosis, thereby increasing...