Increased hepatic lipase (HL) activity is associated with small, dense, low density lipoprotein (LDL) and low high density lipoprotein2 (HDL2) cholesterol (-C) levels. A polymorphism in the promoter region of the HL gene (LIPC) is associated with HDL-C levels. To test whether this association is mediated by differences in HL activity between different LIPC promoter genotypes, the LIPC promoter ...

The inheritance of low density lipoprotein (LDL) subclass patterns was investigated in 234 members of seven large kindreds with familial combined hyperlipidemia (FCHL), a disorder characterized by elevated LDL cholesterol and/or triglyceride and increased coronary disease risk in families. Analysis of LDL subclasses by nondenaturing gradient gel electrophoresis showed a predominance of large, b...

The importance of low-density lipoprotein (LDL) cholesterol in the development of atherosclerosis has long been recognized, and LDL cholesterol remains the primary target of therapy for the prevention of coronary heart disease. Nevertheless, increasing research attention over the past decade has been devoted to the heterogeneity of LDL particles and the atherogenicity of lipids and lipoproteins...

High levels of plasminogen activator inhibitor-1 (PAI-1) and preponderance of small dense low-density lipoproteins (LDL) have both been associated with atherosclerotic disease and with the insulin resistance syndrome (IRS). In vitro studies have shown a stimulatory effect of various lipoproteins on PAI-1 release from different cells, including endothelial cells and adipocytes. The authors sough...

Diabetic foot (DF) is one of the most severe complications diabetes that significantly reduces quality life and survival patients. Besides firmly established risk factors, novel data indicate alterations in lipid metabolism might also be implicated development progression DF. dyslipidemia characterized by atherogenic triad, consisting increased triglycerides (TG), decreased high-density lipopro...

© 2001 Canadian Medical Association or its licensors In his Nobel laureate address, Joseph Goldstein referred to cholesterol as the most decorated molecule in history, and certainly there is a lot of evidence relating the levels of total and low-density lipoprotein (LDL) cholesterol to the risk of vascular disease. But does that mean that they will remain tomorrow in the central position that t...

© 2001 Canadian Medical Association or its licensors In his Nobel laureate address, Joseph Goldstein referred to cholesterol as the most decorated molecule in history, and certainly there is a lot of evidence relating the levels of total and low-density lipoprotein (LDL) cholesterol to the risk of vascular disease. But does that mean that they will remain tomorrow in the central position that t...

PURPOSE In patients suffering from symptomatic peripheral artery disease (PAD), percutaneous revascularization is the treatment of choice. However, restenosis may occur in 10 to 60% in the first year depending on a variety of factors. Small dense low density lipoprotein (sdLDL) particles are associated with an increased risk for cardiovascular events, but their role in the process of restenosis...