Previously, we have shown that Helicobacter pylori can spontaneously and reversibly change its membrane lipid composition, producing variants with low or high content of lysophospholipids. The "lyso" variant contains a high percentage of lysophospholipids, adheres better to epithelial cells, and releases more proteins such as urease and VacA, compared to the "normal" variant, which has a low co...

Staphylococcus aureus is the most prevalent organism isolated from airways of people with cystic fibrosis (CF), predominantly early in life. Yet its role pathology lung disease poorly understood. In mice, and many experiments using cell lines, bacterium invades cells or interstitium, forms abscesses. This at odds limited available clinical data: interstitial bacteria are rare CF biopsies absces...

Abstract Some microorganisms are characterised by the ability to create specific morphological varieties called Small Colony Variants (SCVs). This characteristic was noted, among others, in Gram-positive cocci, mainly staphylococci, but also Gram-negative bacilli. The properties of that differentiate them from wild-type colonies (mainly their small size) facilitate intracellular survival (e.g. ...

We have described the establishment and biochemical characterization of 50 small cell lung carcinoma (SCLC) cell lines. Further analysis of these data, combined with studies of morphology and growth characteristics, indicates that 35 (70%) of the lines retained typical morphology (SCLC, intermediate subtype), growth characteristics (growth as tightly packed floating cellular aggregates, long do...

We have described the establishment and biochemical char acterization of 50 small cell lung carcinoma (SCLC) cell lines. Further analysis of these data, combined with studies of mor phology and growth characteristics, indicates that 35 (70%) of the lines retained typical morphology (SCLC, intermediate sub type), growth characteristics (growth as tightly packed floating cellular aggregates, long...