Basic aspects of heart morphogenesis involving migration, cell polarization, tissue alignment, and lumen formation may be conserved between Drosophila and humans, but little is known about the mechanisms that orchestrate the assembly of the heart tube in either organism. The extracellular-matrix molecule Slit and its Robo-family receptors are conserved regulators of axonal guidance. Here, we re...

Emerging evidence indicates that the neuronal guidance molecule SLIT plays a role in tumor suppression, as SLIT-encoding genes are inactivated in several types of cancer, including lung cancer; however, it is not clear how SLIT functions in lung cancer. Here, our data show that SLIT inhibits cancer cell migration by activating RhoA and that myosin 9b (Myo9b) is a ROBO-interacting protein that s...

Recognition of the large secreted protein Slit by receptors of the Robo family provides fundamental signals in axon guidance and other developmental processes. In Drosophila, Slit-Robo signalling regulates midline crossing and the lateral position of longitudinal axon tracts. We report the functional dissection of Drosophila Slit, using structure analysis, site-directed mutagenesis and in vitro...

Background: Slit skin smears and skin biopsy are the most common techniques used for the diagnosis of cutaneous leishmaniasis (CL) in endemic areas. Aim of work: This study was carried out to compare the predictive value of slit skin smears and skin biopsy in the diagnosis of CL. Patients and Methods: 30 patient were included in the present study with clinically suspected lesions of CL. Their a...

Electron double-slit experiments, the essence of quantum mechanical “wave/particle duality”, have been extensively and continuously studied because their unrealistic interpretations attracted many researchers. Here, we discuss recent sophisticated V-shaped experiments to elucidate electron-path information, i.e., which slit electrons pass through, path they pursue, where arrive interfere on ima...

UNLABELLED The main objective of this work was the development of a skew-slit collimator for small-animal SPECT to replace the state-of-the-art multipinhole collimator. METHODS A pinhole forms a cone-beam imaging geometry. If the collimator rotates around the object in a circular orbit, the projection measurements acquired by the cone-beam imaging geometry are incomplete and not enough for ar...

BACKGROUND Allergen immunotherapy is a recognised intervention in patients with allergies not responding to standard pharmacotherapy or in whom pharmacotherapy is contraindicated. We describe the sublingual immunotherapy (SLIT) regimens used in children and adolescents with house dust mite (HDM) respiratory allergies in France and assess the efficacy and safety of this treatment. METHODS This...

PURPOSE This study investigated the long-term efficacy, safety, and compliance associated with sublingual immunotherapy (SLIT) in Korean patients with allergic rhinitis sensitized to house dust mites. METHODS This is a retrospective cohort study. A total of 164 patients who were sensitized to Dermatophagoides pteronyssinus and Dermatophagoides farinae and who received SLIT were enrolled betwe...

AIMS To assess the reproducibility and validity of a new instrument for grading nuclear cataract-the laser slit lamp, by comparison with an established method of lens grading-the Lens Opacities Classification System III (LOCS III). METHODS 62 volunteers (113 eyes) were examined on two occasions. At each visit, a video image of the anterior segment was captured with the laser slit lamp and sto...

Slit, the ligand for the Roundabout (Robo) receptors, is secreted from midline cells of the Drosophila central nervous system (CNS). It acts as a short-range repellent that controls midline crossing of axons and allows growth cones to select specific pathways along each side of the midline. In addition, Slit directs the migration of muscle precursors and ventral branches of the tracheal system,...