The nuclear factor κB (NF-κB) signalling pathway controls important cellular events such as cell proliferation, differentiation, apoptosis and immune responses. Pathway activation occurs rapidly upon TNFα stimulation and is highly dependent on ubiquitination events. Using cytoplasmic to nuclear translocation of the NF-κB transcription factor family member p65 as a read-out, we screened a synthe...

We explore the superstring theory on AdS3 × S3 × T 4 in the framework given in [1]. We argue on the Hilbert space of “space-time CFT”, especially, construct a suitable vacuum of this CFT from the physical degrees of freedom of the superstring theory in bulk. We first construct explicitly it in the case of p = 1, and then present a proposal for the general cases of p > 1. After giving some compl...

We explore the superstring theory on AdS3×S×T 4 in the framework given in [1]. We argue on the Hilbert space of “space-time CFT”, and especially construct a suitable vacuum of this CFT from the physical degrees of freedom of the superstring theory in bulk. We first construct it explicitly in the case of p = 1, and then present a proposal for the general cases of p > 1. After giving some complet...

Function Equalizer Design Sarat Kumar Patra , Bernard Mulgrew Dept of Electrical Engineering, University of Edinburgh, Edinburgh, EH9 3JL, UK. Tel: +44 131 6505655; fax: +44 131 650 6554 e-mail: [email protected] ABSTRACT This paper investigates the computational aspects of radial basis function (RBF) equalizers. In an RBF implementation of the Bayesian equalizer the RBF centers are placed at equ...

In this letter, a sparse Kronecker-product (SKP) coding scheme is proposed for unsourced multiple access. Specifically, the data of each active user encoded as Kronecker product two component codewords with one being and other forward-error-correction (FEC) coded. At receiver, an iterative decoding algorithm developed, consisting matrix factorization decomposition soft-in soft-out code FEC code...

The aim of this study is to explore the underlying mechanism on berberine-induced Cyclin D1 degradation in human hepatic carcinoma. We observed that berberine could suppress both in vitro and in vivo expression of Cyclin D1 in hepatoma cells. Berberine exhibits dose- and time-dependent inhibition on Cyclin D1 expression in human hepatoma cell HepG2. Berberine increases the phosphorylation of Cy...