BACKGROUND Dermatomyositis (DM) is an autoimmune disease that mainly affects the skin, muscle, and lung. The pathogenesis of skin inflammation in DM is not well understood. METHODOLOGY AND FINDINGS We analyzed genome-wide expression data in DM skin and compared them to those from healthy controls. We observed a robust upregulation of interferon (IFN)-inducible genes in DM skin, as well as sev...

OBJECTIVE Advanced glycation end products (AGEs) are thought to have a role in the pathogenesis of diabetes complications. We recently reported the association between skin autofluorescence, as a measure of tissue AGE accumulation, and diabetic neuropathy in a selected diabetic population. In this study, we investigated the relation between skin autofluorescence and clinical variables including...

Using skincare and facial skin care must be in accordance with the type of skin, because if it is not suitable, can cause problems such as breakouts, dry irritated acne prone skin. To find out you have to do an examination a genital specialist, but high cost consultation long queue process obstacle for everyone. Therefore, authors created expert system identify types using combination certainty...

The checkpoint protein p53, which is activated by DNA damage, is involved in the decision whether the cells should stop replication and proceed to repair their DNA or die by apoptosis. We evaluate the expression of p53 and the number of apoptotic cells in normal sun-exposed (face) and protected (abdomen) skin in Egyptians between 6 and 77 years of age. The degree of p53 expression in facial ski...

BACKGROUND/AIMS Facial sebum secretions are known to change under various circumstances. Facial skin types have been categorized as oily, normal, dry, and combination types. However, these have been evaluated subjectively by individuals to date, and no objective accepted standard measurement method exists. The combination skin type is most common, but its definition is vaguer than the definitio...

Cutaneous human papillomaviruses (HPV) are common in nonmelanoma skin cancers, benign skin lesions, and healthy skin. Increased seroprevalences for cutaneous HPV among nonmelanoma skin cancer patients have been described. To determine whether antibodies to cutaneous HPV are related to presence of the virus and/or to skin disease, we collected serum and biopsies from both lesions and healthy ski...

introduction the first medical intervention for many breast cancer patients is breast conserving surgery (bcs) and/or modified radical mastectomy (mrm). most of these patients undergo radiation therapy, following surgery. the most common side-effect of breast radiotherapy is skin damage. in the present study, the severity of acute skin changes and the underlying causes were investigated in pati...