نتایج جستجو برای: skin tumor
تعداد نتایج: 608087 فیلتر نتایج به سال:
The mechanism for inflammation associated tumor development is a central issue for tumor biology and immunology and remains to be fully elucidated. Although IL-17 is implicated in association with inflammation mediated carcinogenesis, mechanisms are largely elusive. In the current studies, we showed that IL-17 receptor-A gene deficient (IL-17R-/-) mice were resistant to chemical carcinogen-indu...
The maxillary swing approach (MSA) allows access to the retromaxillary area, pterygopalatine fossa, nasopharynx and infratemporal fossa through temporary disarticulation lateral of maxilla with attached facial skin. We report a case resection tumor occupying wide area sinus using modified MSA.
The present study has compared different mouse stocks and strains with known sensitivity to phorbol ester skin tumor promotion for their sensitivities to skin tumor promotion by a prototypic organic peroxide (benzoyl peroxide, BzPo) and anthrone (chrysarobin, Chr) tumor pro moter. Following initiation with either 7,12-dimethylben7.(a)anthracene and/or jV-methyl-/V'-nitro-;V-nitrosoguanidine, gr...
The present study has compared different mouse stocks and strains with known sensitivity to phorbol ester skin tumor promotion for their sensitivities to skin tumor promotion by a prototypic organic peroxide (benzoyl peroxide, BzPo) and anthrone (chrysarobin, Chr) tumor pro moter. Following initiation with either 7,12-dimethylben7.(a)anthracene and/or jV-methyl-/V'-nitro-;V-nitrosoguanidine, gr...
Lutein and zeaxanthin are xanthophyll carotenoids with potent antioxidant properties protecting the skin from acute photodamage. This study extended the investigation to chronic photodamage and photocarcinogenesis. Mice received either a lutein/zeaxanthin-supplemented diet or a standard nonsupplemented diet. Dorsal skin of female Skh-1 hairless mice was exposed to UVB radiation with a cumulativ...
Calcified aponeurotic fibroma is a rare benign fibroblastic tumor. The lesion has property of local invasion and high recurrence. Because this property, tumor should be accurately diagnosed pre-operatively. We report case 29 years old male, with palpable painful mass on the anterior chest wall near left pectoral region, describes radiographic MR findings. No skin defect was detected but patient...
The c-Jun NH(2)-terminal kinase (JNK) has been implicated in regulating cell survival, apoptosis, and transformation. However, the distinct role of JNK isoforms in regulating tumor development is not yet clear. We have found previously that skin tumor formation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), is suppressed in JNK2-deficient (Jnk2(-/-)) mice. Here, we s...
The mitotic kinase Aurora A is an important therapeutic target for cancer therapy. This study evaluated new mechanism-based pharmacodynamic biomarkers in cancer patients in two phase I studies of MLN8054, a small-molecule inhibitor of Aurora A kinase. Patients with advanced solid tumors received MLN8054 orally for 7 consecutive days in escalating dose cohorts, with skin and tumor biopsies obtai...
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