Volume 87, Number 7 www.aafp.org/afp American Family Physician 513 A 32-year-old woman presented with a pruritic skin rash that had appeared intermittently for two years. Initially, the rash involved multiple papules and small plaques on the face, neck, and trunk. The lesions progressed to large plaques with centrifugally spreading edges and central clearing. The patient did not have fever or j...

Lupus erythematosus profundus (LEP) is a rare form of chronic cutaneous lupus erythematosus. We report on a case of a 56-year-old Caucasian woman who presented with a single, persistent, painful rash on the left hip and lateral aspect of the left upper thigh, which had been present for 2.5 years. The patient had a history of previous injury to this area before the rash started. Clinical finding...

Aberrations in cutaneous T-cell immunology may result in rashes that recur at the same or similar sites in the skin, and include fixed drug eruption, psoriasis and mycosis fungoides (MF). Here we describe a patient with an unusual presentation of a cutaneous CD30 + lymphoproliferative disorder, manifesting as a rash with a tendency to repeatedly appear at the same skin locations before spontane...

BACKGROUND The purpose of this study was to evaluate the tolerability of concurrent radiotherapy and cetuximab (bioradiotherapy [BRT]) after taxane-based induction chemotherapy in head and neck squamous cell carcinoma (HNSCC). METHODS One hundred four patients with HNSCC received BRT with (29%) or without (71%) prior taxane-based induction chemotherapy. RESULTS Radiodermatitis (97%) and ski...

Because childhood rashes may be difficult to differentiate by appearance alone, it is important to consider the entire clinical presentation to help make the appropriate diagnosis. Considerations include the appearance and location of the rash; the clinical course; and associated symptoms, such as pruritus or fever. A fever is likely to occur with roseola, erythema infectiosum (fifth disease), ...

A rash is a skin eruption that has a defined morphology and location. The morphology of the rash is usually distinct and related to the pathophysiologic dysfunction of the skin. Most severe rashes begin as exanthems (from the Greek exanthema, which means “breaking out,” and anthos, which means “flowering”). These rashes subsequently take on a particular morphology, characteristic lesions, or di...

We report on a serious side effect in a severely depressed 55-year-old woman, who presented an erythematous pigmented skin rash on the whole body under combination treatment with antidepressants, atypical antipsychotic drugs, the mood stabilizer lithium and the lipid-lowering drug pravastatin. The skin rash effect was most probably due, in first line, to olanzapine, but the cutaneous skin condi...