BACKGROUND Painless, rapid, controlled, minimally invasive molecular transport across human skin for drug delivery and analyte acquisition is of widespread interest. Creation of microconduits through the stratum corneum and epidermis is achieved by stochastic scissioning events localized to typically 250 microm diameter areas of human skin in vivo. METHODS Microscissioning is achieved by a li...

OBJECTIVE To estimate the diagnostic accuracy and the scope of utilisation of a new bio-electronic method of organ diagnostics. DESIGN Double-blind comparative study of the diagnostic results obtained using organ electrodermal diagnostics (OED), with clinical diagnosis as the criterion standard. SETTING Department of Surgery, Helen Joseph Hospital, Johannesburg. PATIENTS Two hundred pre-s...

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Effect of sebum and ointment rubbing was evaluated on the permeation of a model steroidal drug, triamcinolone acetonide (TA), from white petrolatum ointment through excised hairless rat skin. Two kinds of white petrolatum ointment containing TA at a concentration of 1.0% were made using a "pre-applied ointment," which was made by applying and recovering white petrolatum on and from the rat skin...