Background: The purpose of this study was to investigate the possible effects of ischemic preconditioning (IP) on the second choke zone of extensive perforator flap in a rat model, and whether pedicle selection for IP influenced its efficacy. Methods: A rat perforator flap model, encompassing three vascular territories, was used. In total, 60 rats were divided into one control and two IP groups...

BACKGROUND In plastic surgery, skin damage induced by ischemia/reperfusion (I/R) is a multifactorial process that often occurs. Methane gas has been reported to be a new therapeutic gas for attenuating I/R injury. In this study, we assessed the effects of methane-rich saline (MRS) in regulating apoptosis on skin flap I/R injury. METHODS Male Sprague-Dawley rats, 6-8 weeks old, were divided ra...

Skin ischemic necrosis due to vasospasm and/or insufficient vascularity is the most common complication in the distal portion of the skin flap in reconstructive surgery. This project was designed to test our hypothesis that preoperative subdermal injection of adenoviral vectors encoding genes for vascular endothelial growth factor-165 (Ad.VEGF-165) or endothelial nitric oxide (NO) synthase (Ad....

The aim of this study was to describe the scheme, surgical procedures, and clinical outcomes for the early repair of deep wounds of the posterior talocrural region in extensively burned patients with a method combining a superficial temporal fascia free flap with thin split-skin grafting. From January 2013 to February 2016, 9 extensively burned patients with deep tissue defects of the posterior...

BACKGROUND Hyperbaric oxygenation has been used for various purposes, but its clinical application is limited due to its pulmonary toxicity. We evaluated the therapeutic value of normobaric hyperoxygenation (NBO) for vascularized and nonvascularized tissue transplantation. METHODS Tissue oxygen partial pressure (PtO2) was measured for various organs in mice under inspiratory oxygen of 20%, 60...