BACKGROUND Dermal skin substitutes have become a standard of care in burn treatment. OBJECTIVE To compare and assess wound contracture reduction and histologic incorporation into the wound, dermal substitutes were implanted into full-thickness skin wounds in nude mice. MATERIALS AND METHODS Thirty-seven mice received a full-thickness 2 x 2 cm dorsal skin wound, and were either implanted wit...

INTRODUCTION The local treatment in burns larger than 50% of total body surface area is still the great challenge for surgeons. AIM This paper presents a review of different solutions for deep burn wound healing in children and the early outcomes of treatment with combined autologous cell culture technique. MATERIAL AND METHODS For this study, 20 children aged between 4 and 12 years with 55...

BACKGROUND Staged excision and grafting with viable cryopreserved alloskin or fresh pigskin at an early stage is a main strategy for wound management in massive burns. Alloskin is the gold standard of a biological temporary skin substitute, and the main drawback to its wider use is the limited number of donors. In this paper, we compare the use of fresh pigskins to cryopreserved alloskins as te...

BACKGROUND The standard of care for full-thickness burns is tangential excision followed by skin autografting; however, the timing of excision and grafting is subject to debate. The authors compared early (2 days) versus delayed (14 days) excision and grafting in a porcine full-thickness burn model. METHODS Full-thickness burns (n = 12) were created on the backs of two anesthetized pigs and a...

The present study aimed at evaluating the effect of local hyperthermia on the healing of burn wounds. Right and Left flunks of 8 Balb-c mice (as treated and control wounds respectively) were burned. Local hyperthermia was applied only for the burn wounds of the right flunks (the treated wound). Sampling was accomplished on the 6th day for half of the mice and on the 9th day for the other half. ...

Objective- This study was designed to investigate the effect of Lactobacillus plantarum gel on cutaneous burn wound healing in diabetic rats.Design- Randomized experimental studyAnimals- Forty adult male ratsProcedures- Two circular 1 cm cutaneous wounds were created in the dorsum back of each rat. 48 h post-burning, debridement with a 1 cm biopsy punch was performed. The woun...

Abstract Background Early mechanisms underlying the progressive tissue death and regenerative capability of burn wounds are understudied in human skin. A clinically relevant, reproducible model for wound healing is needed to elucidate early changes environment. This study reports a contact on skin that explores extent injury over time, defines inter-individual variability enable use mechanistic...

Burns are among the most common traumas in developing countries, which consume large amounts of medical resources. It is important to find an appropriate material for dressing of burn wounds that improves healing and is readily available, easily applicable, and economical and also be protective from infection and desiccation, and facilitate healing. [1] Most burn injuries happen in people with ...