نتایج جستجو برای: skbr3
تعداد نتایج: 420 فیلتر نتایج به سال:
Inhibitors of fatty acid synthase (FASN), a key enzyme involved in the anabolic conversion of dietary carbohydrates to fat in mammals, are receiving increasingly more attention as they may provide therapeutic moieties for the treatment of human malignancies. Natural compounds, such as the green tea polyphenol epigallocatechin-3-gallate, have been shown to induce anti-cancer effects by suppressi...
herein, 1f2, an anti-her2 monoclonal antibody (mab), was covalently coupled to the surface of 5-fluorouracil (5-fu) loaded bovine serum albumin (bsa) nanoparticles. concerning two different crosslinkers for conjugation of 1f2, maleimide-poly (ethylene glycol)-succinimidyl carbonate (mal-peg5000-nhs) was selected due to its higher conjugation efficiency (23±4 %) obtained in comparison to n-succi...
سابقه و هدف: هرسپتین یک آنتی بادی مونوکلونال انسانی است که برای درمان سرطان پستان مورد استفاده قرار می گیرد. در این تحقیق این آنتی بادی مونوکلونال با لوتشیم-177 به کمک شلاتورpa-dota نشاندارشده و به عنوان اولین قدم، اثر درمانی آن بر روی سه رده سلولی سرطان پستان skbr3، mcf7 و a431 بررسی شد. مواد و روش ها: تست های کنترل کیفی آزمایشگاهی شامل بازده نشاندارسازی، ایمونوراکتیویته، پایداری در بافر و س...
The design, synthesis, and biological evaluation of conformationally constrained coumermycin A1 analogues are reported. Compounds were evaluated against both breast cancer (SKBr3 and MCF7) and prostate cancer (PC3 mm2, A549, and HT29) cell lines. Non-noviosylated coumermycin A1 analogues that manifest potent antiproliferative activity resulting from Hsp90 inhibition are provided, wherein replac...
A pH-responsive drug delivery system composed of N-(propyl)aniline (N-ANI) modified mesoporous silica nanoparticles as a carrier, and β-cyclodextrin (β-CD) cap was prepared investigated. The studied for co-adsorption co-delivery two different drugs; an anticancer 5-fluorouracil (5-FU), anti-inflammatory agent naproxen (NAP). Detailed adsorption study the drugs themselves well in their mutual mi...
Platelet-activating factor receptor (PAF-R) transcripts were analysed by reverse transcriptase-polymerase chain reaction in five human cancer cell lines derived from the breast (BT20, SKBR3 and T47D cells), the pancreas (Miapaca cells) and the bladder (5,637 cells) in order to confirm the existence of a splice variant of the PAF-R transcript 2. After cloning and sequencing, we confirmed its exi...
BACKGROUND Triple-negative breast cancer (TNBC) accounts for 15-20% of breast cancers but is responsible for a disproportionate number of deaths. We investigated the relevance, in TNBC, of nano-sized exosomes expelled from cells. Specifically, we compared effects of exosomes derived from the claudin-low TNBC cell line Hs578T and its more invasive Hs578Ts(i)8 variant, as well as exosomes from TN...
Multifunctional nanoparticles have been reported for cancer detection and treatment currently. However, the accurate diagnosis and efficient treatment for tumors are still not satisfied. Here we report on the development of targeted phase change multimodal polymeric nanoparticles for the imaging and treatment of HER2-positive breast cancer. METHODS We evaluated the multimodal imaging capabili...
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