Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder associated with ciliary defects and situs inversus totalis, the complete mirror image reversal of internal organ situs (positioning). A variable incidence of heterotaxy, or irregular organ situs, also has been reported in PCD patients, but it is not known whether this is elicited by the PCD-causing genetic lesion. We studi...

INTRODUCTION The association of situs inversus totalis (SIT) and VACTERL syndrome an extremely rare coincidence. PATIENTS The patient was first diagnosed as simple SIT with lumbosacral neoplasms according to the prenatal magnetic resonance imaging (MRI) examination; however, the local hospital ignored the important to physical examination so that missed anal atresia with fistula. The patient ...

Recently, we have reported 20 cases of isolated 1lvocardia (Campbell and Deuchar, 1965), and here we are describing 33 cases of dextrocardia with malformations of the heart. These are nearly always present when the heart is on the right side without inversion of the abdominal viscera (isolated dextrocardia), as they are with isolated levocardia: generally they produce a right-to-left shunt and ...

Dextrocardia can be defined as a heart in the right chest with the major axis to the right. This definition, however, conveys no information regarding the chamber arrangements and internal anatomy of the heart. Of 40 patients satisfying this definition in the files of the Brompton Hospital, 33 had angiocardiographic data adequate for complete analysis in terms of connections, relations, and mor...

C liical im ge A term-newborn baby developed respiratory distress after his first feed. An orogastric tube failed to reach the stomach. Chest and abdominal radiography showed a coiled tube in the proximal oesophageal pouch, and a gas-containing abdomen. These findings were consistent with oesophageal atresia (OA) and distal tracheo-esophageal fistula (TOF) (Fig.). Dextrocardia, right-sided gast...

CONTENTS. PAGE 1. I N T R O D U C T I O N . . . . . . . . . 105 2. D E S C R I P T I O N S OT T H E L A H V A E W I T H I N V E R S E S I T U S . . 1 0 7 3. R E S U L T S O F T H E E X P E R I M E N T S . . , . . . 1 1 3 4. C H A N G E S W H I C H M A Y P O S S I B L Y H A V E T A K E N P L A C E DURING* E A R L I E R S T A G E S . . . . . . . . 1 1 7 5. V A R I A T I O N S A M O N O D O U B L ...

We are studying the development of handedness, in particular the relationships between handed structures with bilateral symmetry, for example the limbs, and those with lateral asymmetry, such as the heart, lungs and gut. Asymmetric (unilateral) developmental limb abnormalities can be induced by chemical treatment of mouse embryos, either in utero by acetazolamide, or in culture by misonidazole....

A 45-year-old man had been diagnosed of Kartagener syndrome (KS) in infancy, involving situs inversus or ‘‘mirror’’ position of the abdominal organs (cardiac magnetic resonance images: Figs. 1A, B, C and D. L, liver; G, gastric fundus) with levocardia (Fig. 1E, arrow), associated with congenitally corrected transposition of the great arteries (CTGA), and right aortic arch (Figs. 1C and F, arrow...

BACKGROUND Situs inversus is a rare complication of cystic kidney diseases. Only three genes, INVS (NPHP2), NPHP3 and PKD2 have been proved to be responsible for some cases, while the responsible genes in many others are still unknown. CASE REPORTS Here we report two male patients with situs inversus combined with cystic kidney disease without any family history of polycystic kidney disease. ...