Wound healing is a specific host immune response for restoration of tissue integrity. Experimental studies demonstrated an alteration of growth factors activity due to their reduced synthesis, increased degradation and inactivation. In wound healing platelets play an essential role since they are rich of alpha-granules growth factors (platelet derived growth factor--PDGF; transforming growth fa...

The present investigation was aimed to formulate and characterize ion-activated in-situ gel loaded with Rizatriptan Benzoate (RIZ) for intranasal administration brain targeting. further optimized process formulation parameters by using 32 factorial design. batch having the concentrations of gellan gum HPMC E15 LV 33.83 mg 9.6 respectively. Gel strength mucoadhesive were found be 32.54 sec 2580....

Conventional ophthalmic solutions often eliminate rapidly after administration and can’t provide and maintain an adequate concentration of drug in the precorneal area. This can be overcome by the use of in situ gel forming systems that are instilled as drops into the eye and undergo a sol-gel transition in the culde-sac. The present work describes the formulation and evaluation of an ophthalmic...

A fast and environmentally-friendly methodology has been developed by in situ synthesis of gold nanoparticles (AuNPs) on thermosensitive liposomes different phase-states, obtaining nanohybrids with controllable tunable plasmon modes within the visible/near-infrared region. Lipid phase, charge temperature influence final arrangement AuNPs, so when is performed zwitterionic fluid discrete AuNPs p...

The present investigation deals with the formulation, optimization and evaluation of sodium alginate based floating oral In situ gel of Pantoprazole. Sodium alginate used as a polymer and Calcium carbonate was used as a crosslinking agent. In-situ forming polymeric formulation drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in-si...

The bibliometric data were extracted from the Scopus database to investigate conceptual framework of ocular nanoemulsion and/or in-situ gel drug delivery system using “ocular” AND “nanoemulsion” OR “in-situ gel” keywords. evaluated with RStudio and VOSviewer program. results reveal that publication trends tend increase continually. India is most impactful country, constructive institution Depar...

al2o3-sio2 diphasic gel was synthesized by sol gel route from aluminium nitrate and silicic acid following aqueous phase colloidal interaction. the precursor gel powder was thoroughly characterized by chemical analysis, measurement of surface area and bulk density measurement. the gel powder was further characterized by thermogravimetry, xrd diffraction study of the heat treated samples and sca...