BACKGROUND Extended liver resections are being performed more liberally than ever. The extent of resection of liver metastases, however, is restricted by the volume of the future liver remnant (FLR). An intervention that would both accomplish tumor control and induce compensatory hypertrophy, with good patient tolerability, could improve clinical outcomes. CASE PRESENTATION A 53-year-old woma...

Sirtuins represent a promising new class of conserved histone deacetylases, originally identified in yeast. The activity of the sirtuin (SirT) family - made up of seven members (SirT1-7) - is NAD(+) dependent. Sirtuins target a wide range of cellular proteins in nucleus, cytoplasm, and mitochondria for post-translational modification by acetylation (SirT1, 2, 3, and 5) or ADP-ribosylation (SirT...

Surgical resection is the only potentially curative strategy in the treatment of patients with colorectal liver metastases (CLM). Unfortunately, only about 10%-15% of patients are candidates for resection. Preoperative chemotherapy aims to increase the number of patients that may be eligible for liver resection by downsizing liver metastases. For patients with unresectable, chemotherapy refract...

The liver is an organ that, due to vascularisation and functions, is prone to metastases. Most liver metastases are observed in cases of gastrointestinal cancers in: stomach, colon, gallbladder, and bile ducts. Metastatic lesions are also observed in lung, breast, thyroid, kidney, and pancreatic cancer. One of the best known and most effective ways of liver lesion treatment is Metastasectomy. U...

If objects or patients move during a CT scan, reconstructions suffer from severe motion artifacts. Time dependent computed tomography (4DCT) tries to minimize these artifacts by estimating motion and/or reconstruction simultaneously. Most current methods assume a known deformation or a reconstruction without artifacts at a certain time point. This work explores the possibilities of estimating t...

Zusammenfassung Lebermetastasen treten bei 50 % der Patienten mit kolorektalem Karzinom auf. Bei resektablen Metastasen ist die chirurgische Resektion Therapie Wahl. Steht dies als Option nicht zur Verfügung, primäre Behandlung eine systemische Chemotherapie. Die selektive interne Radiotherapie (SIRT) innovative Behandlungsform für und sekundäre Lebertumoren. Es handelt sich um ein minimal-inva...