AIM To assess the relationship between discordant umbilical arterial size and resultant blood flow parameters and determine the impact of discordance on fetal outcome. METHODS This is a descriptive, cross-sectional study of 200 patients with a singleton gestation, who underwent a fetal anatomy survey between 18 to 23 weeks of gestation, with documented umbilical cord morphological patterns an...

Absence of one umbilical artery is a rare finding, usually associated with other severe congenital malformations. The earliest recorded case is attributed to Casp. Bauhin in 1621, although Noortwyck (1743) quotes Vesalius' description 'unam tantum arteriam in fune Fallopius vidit'. Otto (1830) collected 41 case reports from the literature, and Hyrtl (1870) described 14 cases of his own and foun...

The present study was performed to compare serum concentrations of maternal and fetal angiogenic growth factors in IUGR (intrauterine growth restriction) and normal pregnancy at the time of delivery. VEGF (vascular endothelial growth factor), PlGF (placental growth factor), sFlt-1 (soluble fms-like tyrosine kinase 1), sKDR (soluble kinase domain receptor) and bFGF (basic fibroblast growth facto...

OBJECTIVE To estimate the umbilical artery and vein blood volume flow using B-mode and Doppler ultrasound in the second and third trimesters of pregnancy. DESIGN This was a cross-sectional study of 129 singleton, healthy pregnancies at 23-33 weeks' gestation. The umbilical artery and vein cross-sectional area, time-averaged velocity and pulsatility index were measured in a free loop of cord, ...

BACKGROUND Umbilical artery catheters are often used in unwell neonates. Infection related to the use of these catheters may cause significant morbidity and mortality. The use of prophylactic antibiotics has been advocated for all newborns with umbilical artery catheters in order to reduce the risk of colonisation and acquired infection. Countering this is the possibility that harm, such as the...

1. The aim of this study was to define from umbilical artery flow velocity waveforms absolute peak systolic and time-averaged velocity, fetal heart rate, fetal heart rate variability and flow velocity variability, and the relation between fetal heart rate and velocity variables in early pregnancy.2.A total of 108 women presenting with a normal pregnancy from 10 to 20 weeks of gestation consente...

34 Pre-eclampsia represents a state of increased or prolonged vasoconstriction, partially 35 linked to the potent vasocontractile effect of isoprostanes. The process of Rho A– 36 mediated calcium sensitization is inherent to a state of prolonged contractility in many 37 smooth muscle types. The aims of this study were 1), to investigate mRNA expression 38 levels of Rho A and Rho kinase isoforms...

BACKGROUND Intrapartum factors may have a role in the development of asthma and allergic diseases among offspring. OBJECTIVE To investigate the association between umbilical arterial pH values at birth and asthma, allergic rhinitis, and atopic eczema in children. METHODS We performed a case-control study of 222 asthmatic children and 183 control children aged 5 to 6 years with umbilical art...

34 Pre-eclampsia represents a state of increased or prolonged vasoconstriction, partially 35 linked to the potent vasocontractile effect of isoprostanes. The process of Rho A– 36 mediated calcium sensitization is inherent to a state of prolonged contractility in many 37 smooth muscle types. The aims of this study were 1), to investigate mRNA expression 38 levels of Rho A and Rho kinase isoforms...