We show evidence that DNA double-strand breaks induced in the Drosophila germ line can be repaired very efficiently by the single-strand annealing (SSA) mechanism. A double-strand break was made between two copies of a 1290-bp direct repeat by mobilizing a P transposon. In >80% of the progeny that acquired this chromosome, repair resulted in loss of the P element and loss of one copy of the rep...

Cloud computing has attracted significant attention from research community because of rapid migration rate of Information Technology services to its domain. Advances in virtualization technology has made cloud computing very popular as a result of easier deployment of application services. Tasks are submitted to cloud datacenters to be processed on pay as you go fashion. Task scheduling is one...

A technique for enhanced generation of selected high harmonics in a gas medium, in a high ionization limit, is proposed in this paper. An aperiodically corrugated hollow-core fiber is employed to modulate the intensity of the fundamental laser pulse along the direction of propagation, resulting in multiple quasi-phase-matched high harmonic emissions at the cutoff region. Simulated annealing (SA...

DNA double-strand breaks (DSBs) are one of the most deleterious types of lesions to the genome. Synthesis-dependent strand annealing (SDSA) is thought to be a major pathway of DSB repair, but direct tests of this model have only been conducted in budding yeast and Drosophila To better understand this pathway, we developed an SDSA assay for use in human cells. Our results support the hypothesis ...

Double-strand DNA breaks occur upon exposure of cells to agents such as ionizing radiation and ultraviolet light or indirectly through replication fork collapse at DNA damage sites. If left unrepaired double-strand breaks can cause genome instability and cell death. In response to DNA damage, proteins involved in double-strand break repair by homologous recombination re-localize into discrete n...

Individually Network reconfiguration or Capacitor control perform well in minimizing power loss and improving voltage profile of the distribution system. But for heavy reactive power loads network reconfiguration and for heavy active power loads capacitor placement can not effectively reduce power loss and enhance voltage profiles in the system. In this paper, an hybrid approach that combine ne...

Simulated Annealing (SA) is a powerful stochastic search method applicable to a wide range of problems for which little prior knowledge is available. It can produce very high quality solutions for hard combinatorial optimization problems. However, the computation time required by SA is very large. Various methods have been proposed to reduce the computation time, but they mainly deal with the c...

Simulated annealing (SA) presents an optimization technique with several striking positive and negative features. Perhaps its most salient feature, statistically promising to deliver an optimal solution, in current practice is often spurned to use instead modified faster algorithms, “simulated quenching” (SQ). Using the author’s Adaptive Simulated Annealing (ASA) code, some examples are given w...