Previously, we have proposed a mathematical model based on a modiied Turing mechanism to account for pigmentation patterning in the butterry wing of Papilio dardanus, well-known for the spectacular phenotypic poly-morphism in the female of the species (Sekimura, et al., Proc. Roy. Soc. Lond. B 267, 851-859 (2000)). In the present paper, we use our model to predict the outcome of a number of dii...

background chronic hepatitis b virus (hbv) infection is a multifactorial disease that can result in serious clinical complications. host genetic background especially the genes that encode immunologic factors like inf-γ and its receptor (ifn-γ r) are critical in the pathogenesis of infection. materials and methods genomic dna from peripheral blood samples of 200 chronically hbv infected patient...

objective(s): this study aims to investigate joint association between cholesterol ester transfer protein (cetp) polymorphisms and body mass index (bmi) or birth weight with the risk of dyslipidemia in iranian children and adolescents. materials and methods:this study was conducted as a sub-study of the “school-based nationwide health survey” (caspian-iii). we randomly selected 750 samples from...

objective(s): accumulating evidence has demonstrated that mirnas contribute to various genetic and epigenetic modifications in the pathogenesis of gastric cancer (gc). recent studies focused on the four single nucleotide polymorphisms (snps) of pre-mirnas including rs11614913, rs3746444, rs2910164, and rs2292832. it was suggested that these four snps were significantly associated with the risk ...

conclusions in general, our study suggests that the association between lep/lepr and ghrl/ghsr with overweight/obesity and the related metabolic disturbances is inconclusive. these results may be due to unidentified gene-environment interactions. more investigations are needed to further clarify this association. results the most prevalent leptin/leptin receptor genes (lep/lepr) and ghrelin/ghr...

A novel mycovirus belonging to the proposed family “Fusariviridae” was discovered in Alternaria solani by sequencing a cDNA corresponding double-stranded RNA extracted from this phytopathogenic fungus. The virus tentatively named “Alternaria fusarivirus 1” (AsFV1). AsFV1 has single-stranded positive-sense (+ssRNA) genome of 6845 nucleotides containing three open reading frames (ORFs) and poly(A...

Uncovering DNA sequence variations that correlate with phenotypic changes, e.g., diseases, is the aim of sequence variation studies. Common types sequence variations are Single nucleotide polymorphism (SNP, pronounced snip).SNPs are the third-generation molecular marker. SNP represents a DNA sequence variant of a single base pair with the minor allele occurring in more than 1% of a given popula...

background: obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases.  the aim of this study was to examine the association of insig2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in north indian subjects. methods: the variants were investigated ...