introduction: hepatitis b is a potentially life-threatening infection that causes acute infection and chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma (hcc). interleukin-12 (il12) is responsible for activation of th1 immune responses, leading to possible clearance of hbv infection from the host’s body. the host’s immune-genetic background plays an important role in t...

abstract   background: the disrupted-in-schizophrenia 1 (disc1) gene, on the chromosome position 1q42, was initially identified at the breakpoint of a balanced translocation, t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large scottish family.   methods: our samples included 200 unrelated patients diagnosed with schizophrenia on the basis of dsm-iv criteria and 200 norm...

background polymorphisms in the interferon λ (inf λ) genes on chromosome 19 have been associated with clearance of hepatitis c virus (hcv) induced by interferon and ribavirin therapy however there is no such data available for pakistani patients with hcv infection. objectives in this study, the effects of single nucleotide polymorphisms (snps) have been investigated in response to treatment wit...

introduction radon is a colorless and tasteless gas which exists in most soils. it is a substance that poses a potential risk for lung cancer in case a person is exposed to high levels over long periods of time. the environmental protection agency (epa) estimates that 90% of lung cancers per year are caused by radon. the aim of this paper is to estimate the absorbed doses of 222rn by mcnpx simu...

background and aims. tooth loss may lead to mastication disability, which in turn has important impact on individual’s quality of life. social and psychological factors have been shown to be associated with tooth loss. this study aimed to investigate the social determinants and prevalence of tooth loss, and presence of functional dentition among female heads of household under support of welfar...

background: varicocele is associated with the failure of ipsilateral testicular growth and development, and the symptoms of pain and reduced fertility. the highly condensed structure of the sperm nuclear chromatin is provided by proper expression of transition nuclear protein (tnp) genes, so any dysregulational expression of these genes results in abnormal spermatogenesis and infertility. objec...

results no significant correlation was seen in rs3743527 and rs129081 polymorphism’s allelic and genotypic frequencies between the patient group and control individuals (p value > 0.05). the average frequencies of rs129081 g and c alleles was 40 (58%) and 29 (42%), respectively. in our sample the average frequencies of rs3743527 c and t alleles, were 41 (61%) and 28 (39%), respectively. the res...

it has been suggested that single nucleotide polymorphisms (snps) in genes involved in toll-like receptors (tlrs) pathway may exhibit broad effects on function of this network and might contribute to a range of human diseases. however, the extent to which these variations affect tlr signaling is not well understood. in this study, we adopted a bioinformatics approach to predict the consequences...

using of colloids and polymeric microparticles are gradually increasing. it is observed that thepositive effects of particles stems in both traditional applications such as column pickings,coatings and paints to more recent technologies in diagnostics, drug delivery and optical devicesare well documented. this review focuses on importance of colloids and covers theirapplications on three level:...

nowadays, scheduling problems have a considerable application in production and service systems. in this paper, we consider the scheduling of n jobs on a single machine assuming no machine idleness, non-preemptive jobs and equal process times. in many of previous researches, because of the delivery dalays and holding costs, earliness and tardiness penalties emerge in the form of linear combinat...