Yellow fever mosquito sterol carrier protein (SCP-2) is known to bind to cholesterol. We report here the three-dimensional structure of the complex of SCP-2 from Aedes aegypti with a C16 fatty acid to 1.35-A resolution. The protein fold is exceedingly similar to the human and rabbit proteins, which consist of a five-stranded beta-sheet that exhibits strand order 3-2-1-4-5 with an accompanying l...

OBJECTIVE To investigate the possible neuroprotective effects of selective cerebral perfusion (SCP) during deep hypothermic circulatory arrest on brain oxygenation and metabolism in newborn piglets. METHODS Newborn piglets 2-4 days of age, anesthetized and mechanically ventilated, were used for the study. The animals were placed on cardiopulmonary bypass, cooled to 18 degrees C and put on SCP...

The emergence of noninvasive liquid biopsy procedures as an alternative to surgical biopsies has fueled intensive research effort and investment into the detection cell-free disease biomarkers. By pairing next-generation sequencing (NGS) RT-qPCR technologies on DNA (cfDNA) RNA (cfRNA), respectively, we have established validated a high-throughput quick-turnaround workflow for highly sensitive g...

fusion of two genes at dna level produces a single protein, known as a chimeric protein. immunotoxins are chimeric proteins composed of specific cell targeting and cell killing moieties. bacterial or plant toxins are commonly used as the killing moieties of the chimeric immunotoxins. in this investigation, the catalytic domain of shiga-like toxin (a1) was fused to human granulocyte macrophage c...

PURPOSE/OBJECTIVES To evaluate the feasibility, usability, and satisfaction of a survivorship care plan (SCP) and identify the optimum time for its delivery during the first 12 months after diagnosis. DESIGN Prospective, descriptive, single-arm study. SETTING A National Cancer Institute-designated cancer center in the southeastern United States. SAMPLE 28 nonmetastatic colon cancer surviv...

Fusion of two genes at DNA level produces a single protein, known as a chimeric protein. Immunotoxins are chimeric proteins composed of specific cell targeting and cell killing moieties. Bacterial or plant toxins are commonly used as the killing moieties of the chimeric immunotoxins. In this investigation, the catalytic domain of Shiga-like toxin (A1) was fused to human granulocyte macrophage ...

We perform error probability analysis of the uncoded OFDM fixed gain Amplify-and-Forward (AF) relaying system with subcarrier permutation (SCP). Two SCP schemes, named: the best-to-best SCP (BTB SCP) and the best-to-worst SCP (BTW SCP) are considered. Closedform expressions for the bit error rate (BER) of the above SCP methods are derived. Numerical results manifest that these SCP schemes may o...

Synaptic plasticity can last from a fraction of a second to weeks depending on how it was induced. The mechanisms that underlie short-, intermediate-, and long-term plasticity have been intensively studied at central synapses of both vertebrates and invertebrates; however, peripheral plasticity has not received as much attention. In this study, we investigated the mechanisms that contribute to ...