This paper is to provide some new generalizations of the Pick Theorem. We first derive a point-set version of the Pick Theorem for an arbitrary bounded lattice polyhedron. Then, we use the idea of a weight function of [2] to obtain a weighted version. Other Pick type theorems known to the author for the integral lattice Z2 are reduced to some special cases of this generalization. Finally, using...

The vehicle routing problem with time windows and simultaneous pick-ups deliveries (VRPTWSPD) is one of the main distribution planning problems. VRPTWSPD aims to find best plan that minimizes number used total travelled distance. Due NP-Hard nature VRPTWSPD, practical large-scale instances cannot be solved optimality within acceptable computational times. Therefore, it necessary develop approxi...

We present 2 cases of Niemann Pick disease, type B with secondary sea-blue histiocytosis. Strikingly, in both cases the Pick cells were positive for tartrate resistant acid phosphatase, a finding hitherto described only in Gaucher cells. This report highlights the importance of this finding as a potential cytochemical diagnostic pitfall in the diagnosis of Niemann Pick disease.

Modern architecture research relies heavily on detailed pipeline simulation. Simulating the full execution of an industry standard benchmark can take weeks to months. Statistical sampling and techniques like SimPoint that pick small sets of execution samples have been shown to provide accurate results while significantly reducing simulation time. The inefficiencies in sampling are (a) needing t...

Knowledge across several segments appears to be a necessary ingredient to innovation in the case of an architectural shift. Innovative firms utilize their knowledge stock to confront the competitive market. This paper demonstrates that exploitation of accumulated knowledge leads to architectural innovation. Ironically, in the new development of products with a short life cycle, when a firm disc...

This paper addresses the Electric Vehicle Routing Problem with Simultaneous Pickup and Delivery (EVRP-SPD), in which electric vehicles (EVs) simultaneously deliver goods to pick up from customers. Due limited battery capacity of EVs, their range is shorter than that internal combustion vehicles. In EVRP, addition depot customers, there are also charging stations (CS) because EVs need be charged...

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The Niemann-Pick disease group is now divided into two distinct entities: (1) acid sphingomyelinase-deficient Niemann-Pick disease (ASM-deficient NPD) resulting from mutations in the SMPD1 gene and encompassing type A and type B as well as intermediate forms; (2) Niemann-Pick disease type C (NP-C) including also type D, resulting from mutations in either the NPC1 or the NPC2 gene. Both Niemann-...

In 1914 Albert Niemann, a German pediatrician who primarily studied infant metabolism, published a description of an Ashkenazi Jewish infant with jaundice [5], nervous system and brain impairments, swollen lymph nodes (lymphadenopathy), and an enlarged liver and spleen (hepatosplenomegaly). He reported that these anatomical disturbances resulted in the premature death of the child at the age of...