We analyze the effect of a heterogeneous variance on bump detection in a Gaussian regression model. To this end we allow for a simultaneous bump in the variance and specify its impact on the difficulty to detect the null signal against a single bump with known signal strength. This is done by calculating lower and upper bounds, both based on the likelihood ratio. Lower and upper bounds together...

A fully automated lab-on-a-disc for simultaneous detection of multiple protein biomarkers in raw samples such as whole blood or whole saliva is developed. Based on the bead-based sandwich-type Enzyme-linked immunosorbent assay (ELISA), here a novel centrifugal microfluidic layout was designed and tested to accomplish the simultaneous detection of C-reactive protein (hsCRP), cardiac troponin I (...

We demonstrate a new simultaneous normalized detection technique for fluorescence detection of ultracold atoms in a superposition of ground-state hyperfine levels. Using this technique we observe atom shot-noise limited detection signal-to-noise ratios in excess of 7800:1 per shot and 14400:1 in 1 s.

Enteric and diarrheal diseases are a major cause of childhood illness and death in countries with developing economies. Each year, more than half of a million children under the age of five die from these diseases. We have developed a portable, microfluidic platform capable of simultaneous, multiplexed detection of several of the bacterial pathogens that cause these diseases. This platform can ...

We report a method for simultaneous ionic current measurements of single molecules across up to 16 solid state nanopore channels. Each device, costing less than $20, contains 16 glass nanopores made by laser assisted capillary pulling. We demonstrate simultaneous multichannel detection of double stranded DNA and trapping of DNA origami nanostructures to form hybrid nanopores.

In this paper we present a technique aimed for simultaneous detection of multiple types of gold nanoparticles (GNPs) within a biological sample, using lock-in detection. We image the sample using a number of modulated laser beams that correspond to the number of GNP species that label a given sample. The final image where the GNPs are spatially separated is obtained computationally. The propose...

A PCR-based reverse hybridization system (research prototype kit INNO-LiPA for H. pylori resistance) was developed and evaluated for simultaneous detection of 23S ribosomal DNA point mutations, associated with macrolide resistance in Helicobacter pylori. Fifty-seven H. pylori strains (51 natural, 6 laboratory-derived artificial, 52 resistant, and 5 susceptible strains) were tested by PCR-LiPA (...

We present the first results obtained at CFHT with the TRIDENT infrared camera, dedicated to the detection of faint companions close to bright nearby stars. Its main feature is the acquisition of three simultaneous images in three wavelengths (simultaneous differential imaging) across the methane absorption bandhead at 1.6μm, that enables a precise subtraction of the primary star PSF while keep...

Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were performed with a glassy carbon electrode (GCE) modified with polyglutamic acid (PGA) on the three dihydroxybenzene isomers, catechol (CT), hydroquinone (HQ), and resorcinol (RS). At bare GCE, these isomers exhibited voltammograms with highly overlapped redox peaks that impeded their simultaneous detection in binary and ternar...