BACKGROUND In a previous study, we showed that simvastatin (SIM) therapy normalized sympathetic outflow and cardiovascular reflex regulation in chronic heart failure (CHF). However, the precise neural and cellular pathways for these effects are unknown. We hypothesized that SIM exerts its beneficial effect on autonomic function in CHF by downregulating central angiotensin II (Ang II) and supero...

SIM is a database management system based on the semantic data model. The goal of this research project was the design and implementation of SIM. SIM, an abbreviation for Semantic Information Manager, uses a data model that thrives in capturing the meaning of the data more than other database models. Thus, this higher-level database model enables the database designer and the users to see a con...

We present AutonoVi-Sim, a novel high-fidelity simulation platform for au1 tonomous driving data generation and driving strategy testing. AutonoVi-Sim 2 is a collection of high-level extensible modules which allows the rapid develop3 ment and testing of vehicle configurations and facilitates construction of complex 4 traffic scenarios. Autonovi-Sim supports multiple vehicles with unique steerin...

The purpose of the research was to explore the therapeutic action of simvastatin-loaded poly(ethylene glycol)-b-poly(gamma-benzyl l-glutamate) (PEG-b-PBLG50) on intestinal ischemia/reperfusion injury (II/RI) through downregulating bone morphogenetic protein 4 (BMP4)/cyclooxygenase-2 (COX-2) pathway as compared to free simvastatin (Sim). Sprague Dawley rats were preconditioned with 20 mg/kg Sim ...

In this paper, we identify and exploit opportunities for cooperation between a group of mobile Wireless Body Area Networks (WBANs), forming a Body-to-Body Network (BBN), through inter-body interference detection and subsequent mitigation. Thus, we consider a dynamic system composed of several BBNs and we analyze the joint mutual and cross-technology interference problem due to the utilization o...