Single-gene disorders occur when mutation in a gene causing alteration of gene function while in multifactorial disorders, mutations occur in multiple genes, and these are usually coupled with environmental causes. In addition, in a multifactorial disorder such as diabetes, the complication is under the influence of different genes. For example, in diabetic retinopathy many genes are involved i...

introduction: cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. the aim of the present study was to evaluate oxytocin (ot) induced cardioprotection and its signaling pathways on lactate dehydrogenase (ldh) and creatine kinase-mb isoenzyme (ck-mb) in the anesthetized rats. methods: eighty...

metabolic syndrome is a chronic low-grade inflammation condition which is associated with central obesity, dyslipidemia, insulin resistance and hypertension. inflammation in metabolic syndrome is not only associated with elevated serum inflammatory markers, such as c-reactive protein (crp), but also, is associated with low-grade inflammation in adipose tissue and releasing of adipokines. higher...

long-term potentiation (ltp) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. studies in recent years indicate the importance of molecular pathways in the development of memory and learning. tropomyosin receptor kinase b (trkb) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...

Abstract Pulmonary fibrosis is a devastating disease, and the pathogenesis of this disease not completely clear. Here, medical records 85 Covid-19 cases were collected, among which progression analyzed in detail. Next, data independent acquisition (DIA) quantification proteomics untargeted metabolomics used to screen disease-related signaling pathways through clustering enrichment analysis diff...

Biomarkers in Cancer aims to provide researchers working in this complex, quickly developing field with online, open access to highly relevant scholarly articles by leading international researchers. In a field where the literature is ever-expanding, researchers increasingly need access to up-to-date, high quality scholarly articles on areas of specific contemporary interest. This supplement ai...

Inhibitors of apoptosis signaling in cellular apoptosis. Apoptosis and Cancer related products in the Abcam Biochemicals range.cancer signaling is that cancer cells may become addicted to specific. Ical signaling pathways involved in cancer initiation and progression heavily rely on.The Pathways in Human Cancer poster summarizes some of the key Ras Common pmtein name signaling pathways implicat...