Wnts are the major ligands responsible for activating Wnt signaling pathway through binding to Frizzled proteins (Fzd) as the receptors. Among these ligands, Wnt2 plays the main role in the tumorigenesis of several human cancers especially colorectal cancer (CRC). Therefore, it can be considered as a potential drug target.The aim of this study was to identify potential drug candidates ...

Background: Clinical evidence points to the effective role of genetic factors and intracellular signaling pathways in physiological cardiac hypertrophy. This study aimed to assess the response of PI3K/mTORc1 signaling pathway in cardiac tissue to resistance training in obese diabetic rats. Materials and Methods: For this purpose, 21 male wistar rats (220±20 g) were obese by 6 weeks high fat di...

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

Esophageal cancer (EC) is the sixth main cause of cancer death worldwide. Important genes associated with esophageal cancer include FOXO3, AKT, and GSK3β. Excessive FOXO3 expression inhibits the proliferation of cancer cells. The expression of AKT is involved in controlling cell growth in tumors. GSK3β activity is higher in cancer tissues. Given the effective role of cancer stem cells (CSCs) in...

Abstract GPR133 (ADGRD1), a member of the adhesion GPCR (aGPCR) family, has been recently implicated in pathogenesis glioblastoma. Like other aGPCRs, is characterized by large N-terminus, which possesses conserved autoproteolysis-inducing (GAIN) domain catalyzing cleavage at proteolysis site (GPS), resulting C-terminal fragment (CTF) and an N-terminal (NTF). We showed that dissociation cleaved ...

Long-term potentiation (LTP) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. Studies in recent years indicate the importance of molecular pathways in the development of memory and learning. Tropomyosin receptor kinase B (TrkB) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...

Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...