Growth, known as the relation between liveweight and age, is explained mathematically by functions that have parameters with biological meaning. These parameters are used to describe growth pattern over time and to estimate the expected weight of animals at specific ages. Animal growth generally follows a sigmoidal pattern and several nonlinear functions have been used to describe it. This stud...

Growth of regular echinoids, expressed as test diameter through time, generally shows a sigmoidal pattern. However, when urchin size is considered in terms of test volume we show that growth of the deep-sea echinoid Echinus affinis is ultimately linear, rather than saturating. We construct a simple allometric model of energy allocation that produces linear growth in volume in mature urchins by ...

Received October 31, 2001; accepted November 14, 2001. BACKGROUND. A Phase II study of previously untreated patients with malignant low grade follicular lymphoma given a combination of unlabeled tositumomab and tositumomab labeled with iodine-131 has recently been completed. The responses of these patients have been characterized, and for some of them tumor dosimetry during therapy has been est...

A class of Soblove type multivariate function is approximated by feedforward network with one hidden layer of sigmoidal units and a linear output. By adopting a set of orthogonal polynomial basis and under certain assumptions for the governing activation functions of the neural network, the upper bound on the degree of approximation can be obtained for the class of Soblove functions. The result...

Artificial Neural Networks(ANN) has applications in the various fields. Non linear transformation problems can be solved using ANN. Generally the parameter weight is initialized to some random value. In this paper we have used Sigmoidal FFANN. The training is done using Gaussian learning rate and weights are initialized to zero. It is found that the training of Sigmoidal FFANN can be done even ...

Cytochrome P450 3A4 (CYP3A4) plays a prominent role in the metabolism of a vast array of drugs and xenobiotics and exhibits broad substrate specificities. Most cytochrome P450-mediated reactions follow simple Michaelis-Menten kinetics. These parameters are widely accepted to predict pharmacokinetic and pharmacodynamic consequences in vivo caused by exposure to one or multiple drugs. However, CY...

Conformist transmission, defined as a disproportionate likelihood to copy the majority, is considered a potent mechanism underlying the emergence and stabilization of cultural diversity. However, ambiguity within and across disciplines remains as to how to identify conformist transmission empirically. In most studies, a population level outcome has been taken as the benchmark to evidence confor...

In vitro experiments were conducted to compare k(inact), K(I) and inactivation efficiency (k(inact)/K(I)) of cytochrome P450 (P450) 2C9 by tienilic acid and (+/-)-suprofen using (S)-flurbiprofen, diclofenac, and (S)-warfarin as reporter substrates. Although the inactivation of P450 2C9 by tienilic acid when (S)-flurbiprofen and diclofenac were used as substrates was similar (efficiency of appro...

Visual recognition and interpretation of human-induced actions and events are among the most active research areas in computer vision, pattern recognition, and image understanding [4]. In this work, we develop such a framework for robustly recognizing human actions in video sequences. The contribution of the paper is twofold. First a reliable neural model, the Multi-level Sigmoidal Neural Netwo...

BACKGROUND Hypertrophic cardiomyopathy (HCM) is a disease characterized by substantial genetic, morphologic, and prognostic heterogeneity. Recently, sex-related differences in HCM were reported, with women being older at diagnosis and exhibiting greater left ventricular outflow tract obstruction than men. We sought to evaluate the influence of sex on the HCM phenotype in a large cohort of unrel...